Format

Send to:

Choose Destination

UNC5D unc-5 netrin receptor D [ Homo sapiens (human) ]

Gene ID: 137970, updated on 13-Mar-2020

Summary

Official Symbol
UNC5Dprovided by HGNC
Official Full Name
unc-5 netrin receptor Dprovided by HGNC
Primary source
HGNC:HGNC:18634
See related
Ensembl:ENSG00000156687 MIM:616466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Unc5h4; PRO34692
Expression
Biased expression in brain (RPKM 2.7), duodenum (RPKM 2.4) and 8 other tissues See more
Orthologs

Genomic context

See UNC5D in Genome Data Viewer
Location:
8p12
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (35235475..35796550)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (35092975..35654068)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379368 Neighboring gene uncharacterized LOC105379369 Neighboring gene LSM12 pseudogene 1 Neighboring gene uncharacterized LOC101929550 Neighboring gene uncharacterized LOC112268026 Neighboring gene uncharacterized LOC105379370

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • FLJ16019, KIAA1777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
netrin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
pyramidal neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
netrin receptor UNC5D
Names
netrin receptor Unc5h4
protein unc-5 homolog 4
protein unc-5 homolog D
unc-5 homolog 4
unc-5 homolog D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322818.1NP_001309747.1  netrin receptor UNC5D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB055056, AC013302, AI004193, AK092313, CK904280, CN289823
    Consensus CDS
    CCDS83279.1
    UniProtKB/Swiss-Prot
    Q6UXZ4
    Related
    ENSP00000394303.2, ENST00000453357.6
    Conserved Domains (5) summary
    cd08801
    Location:848945
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:250301
    TSP1; Thrombospondin type 1 repeats
    pfam00791
    Location:538634
    ZU5; ZU5 domain
    pfam17217
    Location:682821
    UPA; UPA domain
    cl11960
    Location:158244
    Ig; Immunoglobulin domain
  2. NM_080872.4NP_543148.2  netrin receptor UNC5D isoform 1 precursor

    See identical proteins and their annotated locations for NP_543148.2

    Status: VALIDATED

    Source sequence(s)
    AB055056, AB073394, AI004193, AK092313, AY358147, BY798317, CK904280, CN289823
    Consensus CDS
    CCDS6093.2
    UniProtKB/Swiss-Prot
    Q6UXZ4
    Related
    ENSP00000385143.2, ENST00000404895.7
    Conserved Domains (5) summary
    cd08801
    Location:853950
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:255306
    TSP1; Thrombospondin type 1 repeats
    pfam00791
    Location:543639
    ZU5; ZU5 domain
    pfam17217
    Location:687826
    UPA; UPA domain
    cl11960
    Location:163249
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    35235475..35796550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013044.1XP_016868533.1  netrin receptor UNC5D isoform X1

  2. XM_017013045.1XP_016868534.1  netrin receptor UNC5D isoform X2

  3. XM_011544401.3XP_011542703.1  netrin receptor UNC5D isoform X5

    See identical proteins and their annotated locations for XP_011542703.1

    Conserved Domains (5) summary
    cd08801
    Location:840937
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:255306
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:161249
    I-set; Immunoglobulin I-set domain
    pfam00791
    Location:529624
    ZU5; ZU5 domain
    cl11960
    Location:163249
    Ig; Immunoglobulin domain
  4. XM_017013046.1XP_016868535.1  netrin receptor UNC5D isoform X3

  5. XM_011544400.2XP_011542702.1  netrin receptor UNC5D isoform X4

    See identical proteins and their annotated locations for XP_011542702.1

    Conserved Domains (5) summary
    cd08801
    Location:842939
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:255306
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:161249
    I-set; Immunoglobulin I-set domain
    pfam00791
    Location:531626
    ZU5; ZU5 domain
    cl11960
    Location:163249
    Ig; Immunoglobulin domain
  6. XM_017013047.1XP_016868536.1  netrin receptor UNC5D isoform X6

  7. XM_011544402.2XP_011542704.1  netrin receptor UNC5D isoform X7

    See identical proteins and their annotated locations for XP_011542704.1

    Conserved Domains (5) summary
    cd08801
    Location:797894
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:255303
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:161249
    I-set; Immunoglobulin I-set domain
    pfam00791
    Location:486581
    ZU5; ZU5 domain
    cl11960
    Location:163249
    Ig; Immunoglobulin domain
  8. XM_011544404.2XP_011542706.1  netrin receptor UNC5D isoform X9

    See identical proteins and their annotated locations for XP_011542706.1

    UniProtKB/TrEMBL
    H7BXJ2
    Related
    ENSP00000287272.2, ENST00000287272.6
    Conserved Domains (5) summary
    cd08801
    Location:784881
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:255303
    TSP1; Thrombospondin type 1 repeats
    pfam00791
    Location:474570
    ZU5; ZU5 domain
    pfam17217
    Location:618757
    UPA; UPA domain
    cl11960
    Location:163249
    Ig; Immunoglobulin domain
  9. XM_011544403.2XP_011542705.1  netrin receptor UNC5D isoform X8

    See identical proteins and their annotated locations for XP_011542705.1

    UniProtKB/TrEMBL
    C9J1I0
    Related
    ENSP00000392739.1, ENST00000420357.5
    Conserved Domains (5) summary
    cd08801
    Location:786883
    Death_UNC5D; Death domain found in Uncoordinated-5D
    smart00209
    Location:255303
    TSP1; Thrombospondin type 1 repeats
    pfam00791
    Location:476572
    ZU5; ZU5 domain
    pfam17217
    Location:620759
    UPA; UPA domain
    cl11960
    Location:163249
    Ig; Immunoglobulin domain
  10. XM_017013050.1XP_016868539.1  netrin receptor UNC5D isoform X10

  11. XM_017013048.1XP_016868537.1  netrin receptor UNC5D isoform X10

  12. XM_017013049.1XP_016868538.1  netrin receptor UNC5D isoform X10

Support Center