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GOT1L1 glutamic-oxaloacetic transaminase 1 like 1 [ Homo sapiens (human) ]

Gene ID: 137362, updated on 25-Jan-2022

Summary

Official Symbol
GOT1L1provided by HGNC
Official Full Name
glutamic-oxaloacetic transaminase 1 like 1provided by HGNC
Primary source
HGNC:HGNC:28487
See related
Ensembl:ENSG00000169154 AllianceGenome:HGNC:28487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis (RPKM 2.6) See more
Orthologs
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Genomic context

See GOT1L1 in Genome Data Viewer
Location:
8p11.23
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (37933548..37940503, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37791799..37797642, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5273 Neighboring gene adrenoceptor beta 3 Neighboring gene Sharpr-MPRA regulatory region 54 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33309

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aspartate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative aspartate aminotransferase, cytoplasmic 2
Names
glutamate oxaloacetate transaminase 1-like protein 1
transaminase A-like protein 1
NP_689626.2
XP_005273456.1
XP_006716348.1
XP_024302827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152413.3NP_689626.2  putative aspartate aminotransferase, cytoplasmic 2

    See identical proteins and their annotated locations for NP_689626.2

    Status: VALIDATED

    Source sequence(s)
    BC029504, BM559469
    Consensus CDS
    CCDS47839.1
    UniProtKB/Swiss-Prot
    Q8NHS2
    Related
    ENSP00000303077.4, ENST00000307599.5
    Conserved Domains (2) summary
    pfam00155
    Location:69395
    Aminotran_1_2; Aminotransferase class I and II
    cl18945
    Location:24399
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    37933548..37940503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447059.1XP_024302827.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X3

    Conserved Domains (1) summary
    cl18945
    Location:7217
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. XM_006716285.3XP_006716348.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X2

    Conserved Domains (2) summary
    pfam00155
    Location:69364
    Aminotran_1_2; Aminotransferase class I and II
    cl18945
    Location:24368
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. XM_005273399.3XP_005273456.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X1

    Conserved Domains (2) summary
    pfam00155
    Location:69394
    Aminotran_1_2; Aminotransferase class I and II
    cl18945
    Location:24398
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RNA

  1. XR_949376.2 RNA Sequence

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