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Got1l1 glutamic-oxaloacetic transaminase 1-like 1 [ Mus musculus (house mouse) ]

Gene ID: 76615, updated on 26-Sep-2022

Summary

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Official Symbol
Got1l1provided by MGI
Official Full Name
glutamic-oxaloacetic transaminase 1-like 1provided by MGI
Primary source
MGI:MGI:1923865
See related
Ensembl:ENSMUSG00000039720 AllianceGenome:MGI:1923865
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700083M11Rik
Summary
Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human GOT1L1 (glutamic-oxaloacetic transaminase 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 22.2) and placenta adult (RPKM 0.7) See more
Orthologs
human all
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Genomic context

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See Got1l1 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27687487..27713872, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27197459..27223845, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene BRF2, RNA polymerase III transcription initiation factor 50kDa subunit Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene RAB11 family interacting protein 1 (class I) Neighboring gene adrenergic receptor, beta 3 Neighboring gene predicted gene 45470

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase? Tanaka-Hayashi A, et al. Amino Acids, 2015 Jan. PMID 25287256, Free PMC Article
  2. Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate. Matsuda S, et al. Amino Acids, 2015 May. PMID 25646960
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The rat and human homologs of mouse GOT1L1 are not involved in D-aspartate biosynthesis.
    Title: Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate.
  2. Got1l1 is not the major aspartate racemase and is highly expressed in the testis, but it is not detected in the brain and submandibular gland.
    Title: Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
putative aspartate aminotransferase, cytoplasmic 2
Names
glutamate oxaloacetate transaminase 1-like protein 1
transaminase A-like protein 1
NP_083950.1
XP_006509274.1
XP_006509276.1
XP_011240469.1
XP_036010262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029674.1 → NP_083950.1  putative aspartate aminotransferase, cytoplasmic 2

    See identical proteins and their annotated locations for NP_083950.1

    Status: PROVISIONAL

    Source sequence(s)
    BC052754
    Consensus CDS
    CCDS22212.1
    UniProtKB/Swiss-Prot
    Q7TSV6, Q9D9F3
    Related
    ENSMUSP00000041337.7, ENSMUST00000038174.8
    Conserved Domains (1) summary
    cl18945
    Location:5 → 399
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    27687487..27713872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509213.5 → XP_006509276.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X2

    Conserved Domains (1) summary
    cl18945
    Location:2 → 359
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  2. XM_011242167.4 → XP_011240469.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X3

    Conserved Domains (1) summary
    cl18945
    Location:2 → 254
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. XM_006509211.5 → XP_006509274.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X1

    See identical proteins and their annotated locations for XP_006509274.1

    UniProtKB/Swiss-Prot
    Q7TSV6, Q9D9F3
    Conserved Domains (1) summary
    cl18945
    Location:5 → 399
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  4. XM_036154369.1 → XP_036010262.1  putative aspartate aminotransferase, cytoplasmic 2 isoform X4

    Conserved Domains (1) summary
    cl18945
    Location:1 → 200
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSV6.1 GenPept UniProtKB/Swiss-Prot:Q7TSV6

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