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Elk4 ELK4, member of ETS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 13714, updated on 26-Sep-2022

Summary

Official Symbol
Elk4provided by MGI
Official Full Name
ELK4, member of ETS oncogene familyprovided by MGI
Primary source
MGI:MGI:102853
See related
Ensembl:ENSMUSG00000026436 AllianceGenome:MGI:102853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sap1; SAP-1; 2310011G17Rik; A130026I01Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within histone H3 deacetylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human ELK4 (ETS transcription factor ELK4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.6), spleen adult (RPKM 6.7) and 27 other tissues See more
Orthologs
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Genomic context

See Elk4 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131935129..131954186)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (132007577..132026448)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene RIKEN cDNA 4833413N01 gene Neighboring gene predicted gene, 37120

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ETS domain-containing protein Elk-4
Names
SRF accessory protein 1
serum response factor accessory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376954.1NP_001363883.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693
    UniProtKB/TrEMBL
    A0A8C6HZJ9
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170349
    PHA03247; large tegument protein UL36; Provisional
  2. NM_001376955.1NP_001363884.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693
    UniProtKB/TrEMBL
    A0A8C6HZJ9
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170349
    PHA03247; large tegument protein UL36; Provisional
  3. NM_001376956.1NP_001363885.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693
    UniProtKB/TrEMBL
    A0A8C6HZJ9
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170349
    PHA03247; large tegument protein UL36; Provisional
  4. NM_001376957.1NP_001363886.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693
    UniProtKB/TrEMBL
    A0A8C6HZJ9
    Related
    ENSMUSP00000027696.4, ENSMUST00000027696.10
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170349
    PHA03247; large tegument protein UL36; Provisional
  5. NM_001376958.1NP_001363887.1  ETS domain-containing protein Elk-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107837
    UniProtKB/Swiss-Prot
    A6H693
    UniProtKB/TrEMBL
    A0A8C6HZJ9
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170349
    PHA03247; large tegument protein UL36; Provisional
  6. NM_001376959.1NP_001363888.1  ETS domain-containing protein Elk-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107837
    Conserved Domains (1) summary
    smart00413
    Location:1769
    ETS; erythroblast transformation specific domain
  7. NM_007923.3NP_031949.2  ETS domain-containing protein Elk-4 isoform 1

    See identical proteins and their annotated locations for NP_031949.2

    Status: VALIDATED

    Source sequence(s)
    AC107837
    Consensus CDS
    CCDS35704.1
    UniProtKB/Swiss-Prot
    A6H693, P41158
    UniProtKB/TrEMBL
    A0A8C6HZJ9
    Related
    ENSMUSP00000083743.6, ENSMUST00000086556.12
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170349
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131935129..131954186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158973.1XP_036014866.1  ETS domain-containing protein Elk-4 isoform X1

    UniProtKB/Swiss-Prot
    A6H693
    UniProtKB/TrEMBL
    A0A8C6HZJ9
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    PHA03247
    Location:170349
    PHA03247; large tegument protein UL36; Provisional