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ELK4 ELK4, ETS transcription factor [ Homo sapiens (human) ]

Gene ID: 2005, updated on 12-Aug-2018

Summary

Official Symbol
ELK4provided by HGNC
Official Full Name
ELK4, ETS transcription factorprovided by HGNC
Primary source
HGNC:HGNC:3326
See related
Ensembl:ENSG00000158711 MIM:600246; Vega:OTTHUMG00000037221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAP1
Summary
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 12.4), lymph node (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See ELK4 in Genome Data Viewer
Location:
1q32.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (205607943..205632872, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205577071..205602971, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC284578 Neighboring gene RNA, U2 small nuclear 19, pseudogene Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene RNA, U6 small nuclear 418, pseudogene Neighboring gene GABA type A receptor-associated protein pseudogene Neighboring gene solute carrier family 45 member 3 Neighboring gene uncharacterized LOC105371701 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434N185

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ETS domain-containing protein Elk-4
Names
ELK4, ETS-domain protein (SRF accessory protein 1)
SAP-1
serum response factor accessory protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029563.1 RefSeqGene

    Range
    5001..29930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001973.3NP_001964.2  ETS domain-containing protein Elk-4 isoform a

    See identical proteins and their annotated locations for NP_001964.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes the longer isoform (1).
    Source sequence(s)
    AC096533, AI002107, AI005122, AL117645, BC040145, BE041598, BE675475, BE676052, BF433322, M85165
    Consensus CDS
    CCDS1456.1
    UniProtKB/Swiss-Prot
    P28324
    UniProtKB/TrEMBL
    A0A024R9C2, Q8IXL1
    Related
    ENSP00000350681.4, OTTHUMP00000035338, ENST00000357992.8, OTTHUMT00000090615
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    pfam04929
    Location:237323
    Herpes_DNAp_acc; Herpes DNA replication accessory factor
  2. NM_021795.2NP_068567.1  ETS domain-containing protein Elk-4 isoform b

    See identical proteins and their annotated locations for NP_068567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. This results in a shorter protein (isoform b) which has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI002107, AI005122, BC040145, BE675475, BE676052, BF433322, BX346360, M85164, T27937
    Consensus CDS
    CCDS1457.1
    UniProtKB/Swiss-Prot
    P28324
    UniProtKB/TrEMBL
    A0A024R997, Q8IXL1
    Related
    ENSP00000289703.4, OTTHUMP00000035339, ENST00000289703.8, OTTHUMT00000090616
    Conserved Domains (2) summary
    smart00413
    Location:1788
    ETS; erythroblast transformation specific domain
    cl26464
    Location:167350
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    205607943..205632872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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