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PRSS58 serine protease 58 [ Homo sapiens (human) ]

Gene ID: 136541, updated on 12-Oct-2019

Summary

Official Symbol
PRSS58provided by HGNC
Official Full Name
serine protease 58provided by HGNC
Primary source
HGNC:HGNC:39125
See related
Ensembl:ENSG00000258223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRY1; PRSS1; TRYX3; UNQ2540
Summary
This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See PRSS58 in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (142252143..142258058, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141951958..141957878, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene maltase-glucoamylase 2 (putative) Neighboring gene monooxygenase DBH like 2, pseudogene Neighboring gene trypsinogen-like pseudogene Neighboring gene PRSS3 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ16649, MGC35022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine protease 58
Names
protease, serine 58
trypsin-X3
NP_001001317.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001333.2 

    Range
    44679..50598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001317.5NP_001001317.1  serine protease 58 precursor

    See identical proteins and their annotated locations for NP_001001317.1

    Status: REVIEWED

    Source sequence(s)
    AA625766, AK122940
    Consensus CDS
    CCDS5871.1
    UniProtKB/Swiss-Prot
    Q8IYP2
    Related
    ENSP00000447588.2, ENST00000547058.6
    Conserved Domains (1) summary
    smart00020
    Location:29234
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    142252143..142258058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    214043..219958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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