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Edil3 EGF-like repeats and discoidin I-like domains 3 [ Mus musculus (house mouse) ]

Gene ID: 13612, updated on 2-Jul-2024

Summary

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Official Symbol
Edil3provided by MGI
Official Full Name
EGF-like repeats and discoidin I-like domains 3provided by MGI
Primary source
MGI:MGI:1329025
See related
Ensembl:ENSMUSG00000034488 AllianceGenome:MGI:1329025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Del1; Del-1; Sox2Cre; Sox2-cre; Tg(Sox2-cre)1Amc
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Predicted to be located in extracellular region. Is expressed in several structures, including cartilage; heart; pinna; skeletal system; and trachea. Orthologous to human EDIL3 (EGF like repeats and discoidin domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 12.8), cerebellum adult (RPKM 11.2) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Edil3 in Genome Data Viewer
Location:
13 C3; 13 45.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (88969591..89471344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (88821472..89323225)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35219 Neighboring gene predicted gene, 19139 Neighboring gene predicted gene, 34585 Neighboring gene enolase 2, gamma neuronal pseudogene Neighboring gene STARR-seq mESC enhancer starr_35220 Neighboring gene STARR-seq mESC enhancer starr_35221 Neighboring gene predicted gene, 38504 Neighboring gene stomatin (Epb7.2)-like 2 pseudogene Neighboring gene predicted gene, 46433 Neighboring gene STARR-seq mESC enhancer starr_35222 Neighboring gene STARR-positive B cell enhancer mm9_chr13:89593474-89593775 Neighboring gene predicted gene, 34699 Neighboring gene hyaluronan and proteoglycan link protein 1 Neighboring gene acylglycerol kinase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EDIL3 influenced the αvβ3-FAK/MEK/ERK axis of endothelial cells in psoriasis. Niu X, et al. J Cell Mol Med, 2022 Oct. PMID 36065978, Free PMC Article
  2. Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation. Failer T, et al. J Clin Invest, 2022 Mar 15. PMID 35133978, Free PMC Article
  3. EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization. Wei X, et al. Cardiovasc Res, 2022 Jul 20. PMID 34375400
  4. Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo. Pokrass MJ, et al. Dev Cell, 2020 Nov 9. PMID 33091369, Free PMC Article
  5. The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration. Yuh DY, et al. J Biol Chem, 2020 May 22. PMID 32280065, Free PMC Article

See all (543) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Developmental endothelial locus-1 promotes osteogenic differentiation and alveolar bone regeneration in experimental periodontitis with type 2 diabetes mellitus.
    Title: Developmental endothelial locus-1 promotes osteogenic differentiation and alveolar bone regeneration in experimental periodontitis with type 2 diabetes mellitus.
  2. Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination.
    Title: Epidermal Growth Factor-Like Repeats and Discoidin I-Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination.
  3. Del-1 Plays a Protective Role against COPD Development by Inhibiting Inflammation and Apoptosis.
    Title: Del-1 Plays a Protective Role against COPD Development by Inhibiting Inflammation and Apoptosis.
  4. DEL-1 deficiency aggravates pressure overload-induced heart failure by promoting neutrophil infiltration and neutrophil extracellular traps formation.
    Title: DEL-1 deficiency aggravates pressure overload-induced heart failure by promoting neutrophil infiltration and neutrophil extracellular traps formation.
  5. Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus.
    Title: Del1 Is a Growth Factor for Skeletal Progenitor Cells in the Fracture Callus.
  6. EDIL3 influenced the alphavbeta3-FAK/MEK/ERK axis of endothelial cells in psoriasis.
    Title: EDIL3 influenced the αvβ3-FAK/MEK/ERK axis of endothelial cells in psoriasis.
  7. EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization.
    Title: EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization.
  8. Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation.
    Title: Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation.
  9. Obesity and altered angiogenic-related gene expression in endometrial cancer.
    Title: Obesity and altered angiogenic-related gene expression in endometrial cancer.
  10. Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK/HO-1- pathway.
    Title: Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK/HO-1- pathway.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EGF-like repeat and discoidin I-like domain-containing protein 3
Names
developmental endothelial locus-1
developmentally-regulated endothelial cell locus 1 protein
integrin-binding protein DEL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037987.4 → NP_001033076.1  EGF-like repeat and discoidin I-like domain-containing protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001033076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC121916, AC154668, AC161244, CT010458
    Consensus CDS
    CCDS26669.1
    UniProtKB/Swiss-Prot
    O35474, O35475, Q8CBF7
    Related
    ENSMUSP00000080462.7, ENSMUST00000081769.13
    Conserved Domains (4) summary
    smart00231
    Location:157 → 314
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00054
    Location:119 → 155
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:160 → 313
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00008
    Location:26 → 58
    EGF; EGF-like domain

  2. NM_010103.4 → NP_034233.1  EGF-like repeat and discoidin I-like domain-containing protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_034233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an internal, in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (b) missing a 10 aa protein segment compared to isoform a.
    Source sequence(s)
    AK046885, AK081003, AK139093, BY701378
    Consensus CDS
    CCDS26670.1
    UniProtKB/TrEMBL
    Q8C4U8
    Related
    ENSMUSP00000044652.7, ENSMUST00000043111.7
    Conserved Domains (4) summary
    smart00231
    Location:147 → 304
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00054
    Location:109 → 145
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:150 → 303
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00008
    Location:26 → 58
    EGF; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    88969591..89471344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35474.2 GenPept UniProtKB/Swiss-Prot:O35474

Gene LinkOut

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