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Ect2 ect2 oncogene [ Mus musculus (house mouse) ]

Gene ID: 13605, updated on 14-Jan-2023

Summary

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Official Symbol
Ect2provided by MGI
Official Full Name
ect2 oncogeneprovided by MGI
Primary source
MGI:MGI:95281
See related
Ensembl:ENSMUSG00000027699 AllianceGenome:MGI:95281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables small GTPase binding activity. Involved in positive regulation of neuron differentiation and positive regulation of protein import into nucleus. Acts upstream of or within cell morphogenesis. Located in cytoplasm and nucleus. Is expressed in brain ventricular layer; liver; and rest of cerebellum marginal layer. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 11.1) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Ect2 in Genome Data Viewer
Location:
3; 3 A3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27151371..27208402, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27097222..27154253, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 16 Neighboring gene predicted gene, 32458 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene RIKEN cDNA 1700125G22 gene Neighboring gene predicted gene, 25152 Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene predicted gene, 42192 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The dynamic behavior of Ect2 in response to DNA damage. He D, et al. Sci Rep, 2016 Apr 14. PMID 27074761, Free PMC Article
  2. Expression of a Rho guanine nucleotide exchange factor, Ect2, in the developing mouse pituitary. Islam MS, et al. J Neuroendocrinol, 2010 May. PMID 20141573
  3. Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles. Elbaz J, et al. Endocrinology, 2010 Feb. PMID 19996184
  4. Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. Saito S, et al. J Biol Chem, 2004 Feb 20. PMID 14645260
  5. Assignment of the ect2 protooncogene to mouse chromosome band 3B by in situ hybridization. Takai S, et al. Cytogenet Cell Genet, 1998. PMID 9691182

See all (50) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the oncogene ECT2 contributes to epithelial cell reprogramming in idiopathic pulmonary fibrosis
    Title: The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis.
  2. Loss of ECT2 expression is associated with myocardial Polyploidization Creating a Barrier to Heart Regeneration.
    Title: Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish.
  3. These results suggest that Ect2 plays roles in multiple aspects of DNA damage response.
    Title: The dynamic behavior of Ect2 in response to DNA damage.
  4. It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
    Title: Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
  5. Ect2 may play a role in neuronal differentiation and brain development in vivo.
    Title: Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells.
  6. results demonstrate the functional role of Ect2 in postnatal proliferating cells in the two lobes of the pituitary, thereby suggesting roles in developmental growth of the mammalian pituitary
    Title: Expression of a Rho guanine nucleotide exchange factor, Ect2, in the developing mouse pituitary.
  7. indispensable role of the maturation-promoting factor ECT2 pathwy in polar body extrusion in mouse oocytes
    Title: Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles.
  8. ECT2 has a role in activating the Rho signaling pathways leading to malignant transformation
    Title: Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4037

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
part_of centralspindlin complex ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein ECT2
Names
epithelial cell-transforming sequence 2 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177625.2 → NP_001171096.1  protein ECT2 isoform 2

    See identical proteins and their annotated locations for NP_001171096.1

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280
    Consensus CDS
    CCDS50875.1
    UniProtKB/Swiss-Prot
    Q07139
    Related
    ENSMUSP00000135740.3, ENSMUST00000176242.9
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. NM_001177626.2 → NP_001171097.1  protein ECT2 isoform 2

    See identical proteins and their annotated locations for NP_001171097.1

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280
    Consensus CDS
    CCDS50875.1
    UniProtKB/Swiss-Prot
    Q07139
    Related
    ENSMUSP00000103933.3, ENSMUST00000108298.9
    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  3. NM_001409697.1 → NP_001396626.1  protein ECT2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  4. NM_001409704.1 → NP_001396633.1  protein ECT2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280
    UniProtKB/Swiss-Prot
    Q8R3E2

  5. NM_001409705.1 → NP_001396634.1  protein ECT2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280
    UniProtKB/Swiss-Prot
    Q8R3E2

  6. NM_001409706.1 → NP_001396635.1  protein ECT2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280
    UniProtKB/Swiss-Prot
    Q8R3E2

  7. NM_001409707.1 → NP_001396636.1  protein ECT2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  8. NM_001409708.1 → NP_001396637.1  protein ECT2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280
    UniProtKB/Swiss-Prot
    Q8R3E2

  9. NM_001409709.1 → NP_001396638.1  protein ECT2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  10. NM_001409710.1 → NP_001396639.1  protein ECT2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  11. NM_001409711.1 → NP_001396640.1  protein ECT2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  12. NM_001409712.1 → NP_001396641.1  protein ECT2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  13. NM_001409713.1 → NP_001396642.1  protein ECT2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  14. NM_001409714.1 → NP_001396643.1  protein ECT2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  15. NM_001409715.1 → NP_001396644.1  protein ECT2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  16. NM_001409716.1 → NP_001396645.1  protein ECT2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  17. NM_001409717.1 → NP_001396646.1  protein ECT2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  18. NM_001409718.1 → NP_001396647.1  protein ECT2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  19. NM_001409719.1 → NP_001396648.1  protein ECT2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  20. NM_001409720.1 → NP_001396649.1  protein ECT2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  21. NM_001409721.1 → NP_001396650.1  protein ECT2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  22. NM_001409722.1 → NP_001396651.1  protein ECT2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  23. NM_001409723.1 → NP_001396652.1  protein ECT2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  24. NM_001409724.1 → NP_001396653.1  protein ECT2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  25. NM_001409725.1 → NP_001396654.1  protein ECT2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280

  26. NM_007900.4 → NP_031926.2  protein ECT2 isoform 1

    See identical proteins and their annotated locations for NP_031926.2

    Status: VALIDATED

    Source sequence(s)
    AC121099, AC165280
    Consensus CDS
    CCDS17270.2
    UniProtKB/Swiss-Prot
    Q07139, Q8R3E2
    Related
    ENSMUSP00000103935.2, ENSMUST00000108300.8
    Conserved Domains (5) summary
    PRK09630
    Location:71 → 125
    PRK09630; DNA topoisomerase IV subunit A; Provisional
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    27151371..27208402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535385.4 → XP_006535448.1  protein ECT2 isoform X1

    UniProtKB/Swiss-Prot
    Q07139
    Conserved Domains (5) summary
    PRK09630
    Location:71 → 125
    PRK09630; DNA topoisomerase IV subunit A; Provisional
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  2. XM_036162884.1 → XP_036018777.1  protein ECT2 isoform X2

    Conserved Domains (4) summary
    smart00325
    Location:425 → 609
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:600 → 773
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:239 → 318
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:145 → 220
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

  3. XM_006535386.4 → XP_006535449.1  protein ECT2 isoform X1

    UniProtKB/Swiss-Prot
    Q07139
    Conserved Domains (5) summary
    PRK09630
    Location:71 → 125
    PRK09630; DNA topoisomerase IV subunit A; Provisional
    smart00325
    Location:456 → 640
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01229
    Location:631 → 804
    PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
    cd17732
    Location:270 → 349
    BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    cd17733
    Location:176 → 251
    BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07139.2 GenPept UniProtKB/Swiss-Prot:Q07139

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