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TAAR1 trace amine associated receptor 1 [ Homo sapiens (human) ]

Gene ID: 134864, updated on 24-Nov-2020

Summary

Official Symbol
TAAR1provided by HGNC
Official Full Name
trace amine associated receptor 1provided by HGNC
Primary source
HGNC:HGNC:17734
See related
Ensembl:ENSG00000146399 MIM:609333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TA1; TAR1; TRAR1
Summary
The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
Orthologs

Genomic context

See TAAR1 in Genome Data Viewer
Location:
6q23.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (132643312..132659182, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132966123..132967142, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 3, pseudogene Neighboring gene trace amine associated receptor 2 Neighboring gene HLF pseudogene 1 Neighboring gene vanin 1 Neighboring gene cyclin G1 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection upregulates TAAR1 in lymph nodes of infected patients PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126874, MGC138399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
trace-amine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
trace amine-associated receptor 1
Names
trace amine receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138327.4NP_612200.1  trace amine-associated receptor 1

    See identical proteins and their annotated locations for NP_612200.1

    Status: VALIDATED

    Source sequence(s)
    AL032821, AL513524
    Consensus CDS
    CCDS5158.1
    UniProtKB/Swiss-Prot
    Q96RJ0
    Related
    ENSP00000275216.1, ENST00000275216.2
    Conserved Domains (2) summary
    pfam00001
    Location:40304
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:38319
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    132643312..132659182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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