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UBLCP1 ubiquitin like domain containing CTD phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 134510, updated on 7-Jan-2024

Summary

Official Symbol
UBLCP1provided by HGNC
Official Full Name
ubiquitin like domain containing CTD phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:28110
See related
Ensembl:ENSG00000164332 MIM:609867; AllianceGenome:HGNC:28110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPUB1
Summary
Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 19.2), brain (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

See UBLCP1 in Genome Data Viewer
Location:
5q33.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (159263290..159286036)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (159791779..159814534)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (158690298..158713044)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 145 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158634672-158635327 Neighboring gene uncharacterized LOC107986468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23544 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene long intergenic non-protein coding RNA 1932 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158689523-158690030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158690031-158690538 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:158728900-158730099 Neighboring gene uncharacterized LOC105377683 Neighboring gene RNA, U4atac small nuclear 2, pseudogene Neighboring gene interleukin 12B

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25267, MGC10067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome regulatory particle binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of proteasome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-like domain-containing CTD phosphatase 1
Names
CTD phosphatase-like with ubiquitin domain 1
CTD-like phosphatase domain-containing protein
nuclear proteasome inhibitor UBLCP1
NP_659486.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145049.5NP_659486.2  ubiquitin-like domain-containing CTD phosphatase 1

    See identical proteins and their annotated locations for NP_659486.2

    Status: VALIDATED

    Source sequence(s)
    AC011418, AY444562, DA930581
    Consensus CDS
    CCDS4345.1
    UniProtKB/Swiss-Prot
    D3DQJ7, Q8WVY7, Q96DK5
    Related
    ENSP00000296786.6, ENST00000296786.8
    Conserved Domains (2) summary
    TIGR02245
    Location:117311
    HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
    cd01813
    Location:377
    Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    159263290..159286036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    159791779..159814534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)