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Ublcp1 ubiquitin-like domain containing CTD phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 79560, updated on 9-Mar-2023

Summary

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Official Symbol
Ublcp1provided by MGI
Official Full Name
ubiquitin-like domain containing CTD phosphatase 1provided by MGI
Primary source
MGI:MGI:1933105
See related
Ensembl:ENSMUSG00000041231 AllianceGenome:MGI:1933105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930527B16Rik; 8430435I17Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in testis. Orthologous to human UBLCP1 (ubiquitin like domain containing CTD phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 11.4), placenta adult (RPKM 10.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ublcp1 in Genome Data Viewer
Location:
11; 11 B1.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (44345398..44361540, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (44454571..44470713, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12153 Neighboring gene interleukin 12b Neighboring gene adenosine kinase pseudogene Neighboring gene ring finger protein 145 Neighboring gene predicted gene, 51891

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Sasaki N, et al. Genomics, 1998 Apr 15. PMID 9598303
  2. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  3. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7513, MGC117826

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome regulatory particle binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-like domain-containing CTD phosphatase 1
Names
nuclear proteasome inhibitor UBLCP1
NP_077795.2
XP_006534585.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024475.5 → NP_077795.2  ubiquitin-like domain-containing CTD phosphatase 1

    See identical proteins and their annotated locations for NP_077795.2

    Status: VALIDATED

    Source sequence(s)
    AK147744, BQ177022, CJ061422
    Consensus CDS
    CCDS24564.1
    UniProtKB/Swiss-Prot
    Q8BGR9, Q99LT3
    UniProtKB/TrEMBL
    A0A6P5QGQ5, A0A8C6HX96
    Related
    ENSMUSP00000099859.4, ENSMUST00000102795.4
    Conserved Domains (2) summary
    TIGR02245
    Location:117 → 311
    HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
    cd01813
    Location:3 → 77
    Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    44345398..44361540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534522.4 → XP_006534585.1  ubiquitin-like domain-containing CTD phosphatase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534585.1

    UniProtKB/Swiss-Prot
    Q8BGR9, Q99LT3
    UniProtKB/TrEMBL
    A0A6P5QGQ5, A0A8C6HX96
    Conserved Domains (2) summary
    TIGR02245
    Location:117 → 311
    HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
    cd01813
    Location:3 → 77
    Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGR9.1 GenPept UniProtKB/Swiss-Prot:Q8BGR9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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