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Cdk2ap1 cyclin dependent kinase 2 associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13445, updated on 21-Apr-2024

Summary

Official Symbol
Cdk2ap1provided by MGI
Official Full Name
cyclin dependent kinase 2 associated protein 1provided by MGI
Primary source
MGI:MGI:1202069
See related
Ensembl:ENSMUSG00000029394 AllianceGenome:MGI:1202069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p12; Doc1; ST19; Apc10; DORC1; doc-1; Cdkap1
Summary
Predicted to enable DNA polymerase binding activity. Acts upstream of or within face morphogenesis and in utero embryonic development. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in retina. Orthologous to human CDK2AP1 (cyclin dependent kinase 2 associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 155.0), CNS E14 (RPKM 126.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 F; 5 63.53 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124483502..124492691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124345439..124354628, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 9 Neighboring gene mitochondrial translation release factor in rescue Neighboring gene strawberry notch 1 Neighboring gene STARR-seq mESC enhancer starr_14338 Neighboring gene STARR-positive B cell enhancer ABC_E851 Neighboring gene lysine methyltransferase 5A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102310, MGC117818

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 2-associated protein 1
Names
CDK2 (cyclin-dependent kinase 2)-associated protein 1
CDK2-associated protein 1
deleted in oral cancer 1
putative oral cancer suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013812.2NP_038840.2  cyclin-dependent kinase 2-associated protein 1

    See identical proteins and their annotated locations for NP_038840.2

    Status: VALIDATED

    Source sequence(s)
    AA190126, AK004852, BE623061
    Consensus CDS
    CCDS39279.1
    UniProtKB/Swiss-Prot
    B2RV53, O35207, Q3SYK3, Q6ZWZ1
    Related
    ENSMUSP00000031341.5, ENSMUST00000031341.11
    Conserved Domains (1) summary
    pfam09806
    Location:61113
    CDK2AP; Cyclin-dependent kinase 2-associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124483502..124492691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)