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Dld dihydrolipoamide dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 13382, updated on 8-Feb-2024

Summary

Official Symbol
Dldprovided by MGI
Official Full Name
dihydrolipoamide dehydrogenaseprovided by MGI
Primary source
MGI:MGI:107450
See related
Ensembl:ENSMUSG00000020664 AllianceGenome:MGI:107450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in placenta adult (RPKM 46.8), heart adult (RPKM 46.1) and 24 other tissues See more
Orthologs
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Genomic context

See Dld in Genome Data Viewer
Location:
12 A2; 12 13.43 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31381561..31401470, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31331562..31351471, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32899 Neighboring gene predicted gene, 24613 Neighboring gene laminin B1 Neighboring gene STARR-positive B cell enhancer ABC_E7129 Neighboring gene STARR-seq mESC enhancer starr_31853 Neighboring gene STARR-seq mESC enhancer starr_31854 Neighboring gene tripartite motif-containing 13 pseudogene Neighboring gene solute carrier family 26, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables dihydrolipoyl dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dihydrolipoyl dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dihydrolipoyl dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipoamide binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to pyruvate dehydrogenase (NAD+) activity IC
Inferred by Curator
more info
PubMed 
contributes_to pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of acetyltransferase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in acrosomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
part_of dihydrolipoyl dehydrogenase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of mitochondrial alpha-ketoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial pyruvate dehydrogenase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of mitochondrial pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of oxoglutarate dehydrogenase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dihydrolipoyl dehydrogenase, mitochondrial
Names
branched chain alpha-keto acid dehydrogenase complex subunit E3
NP_031887.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007861.5NP_031887.2  dihydrolipoyl dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031887.2

    Status: REVIEWED

    Source sequence(s)
    AI849462, AK117104, BY282701
    Consensus CDS
    CCDS36428.1
    UniProtKB/Swiss-Prot
    O08749, Q3TG55, Q3U5W5, Q3UWP7, Q99LD3
    UniProtKB/TrEMBL
    Q3TIE8
    Related
    ENSMUSP00000106481.4, ENSMUST00000110857.5
    Conserved Domains (1) summary
    cl26177
    Location:43508
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    31381561..31401470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)