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Dld dihydrolipoamide dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 13382, updated on 12-Aug-2018

Summary

Official Symbol
Dldprovided by MGI
Official Full Name
dihydrolipoamide dehydrogenaseprovided by MGI
Primary source
MGI:MGI:107450
See related
Ensembl:ENSMUSG00000020664
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in placenta adult (RPKM 46.8), heart adult (RPKM 46.1) and 24 other tissues See more
Orthologs

Genomic context

See Dld in Genome Data Viewer
Location:
12 A2; 12 13.43 cM
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (31331562..31351471, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (32016427..32036302, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32899 Neighboring gene laminin B1 Neighboring gene tripartite motif-containing 13 pseudogene Neighboring gene solute carrier family 26, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD binding ISO
Inferred from Sequence Orthology
more info
 
dihydrolipoyl dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
dihydrolipoyl dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
lipoamide binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to pyruvate dehydrogenase (NAD+) activity IC
Inferred by Curator
more info
PubMed 
contributes_to pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
dihydrolipoamide metabolic process ISO
Inferred from Sequence Orthology
more info
 
gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone succinylation ISO
Inferred from Sequence Orthology
more info
 
lipoate metabolic process ISO
Inferred from Sequence Orthology
more info
 
mitochondrial acetyl-CoA biosynthetic process from pyruvate IC
Inferred by Curator
more info
PubMed 
mitochondrial acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
mitochondrial electron transport, NADH to ubiquinone IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
sperm capacitation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
acrosomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
motile cilium IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 
pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dihydrolipoyl dehydrogenase, mitochondrial
Names
branched chain alpha-keto acid dehydrogenase complex subunit E3
NP_031887.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007861.5NP_031887.2  dihydrolipoyl dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031887.2

    Status: REVIEWED

    Source sequence(s)
    AI849462, AK117104, BY282701
    Consensus CDS
    CCDS36428.1
    UniProtKB/Swiss-Prot
    O08749
    Related
    ENSMUSP00000106481.3, ENSMUST00000110857.4
    Conserved Domains (1) summary
    cl26177
    Location:43508
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    31331562..31351471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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