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Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 13358, updated on 8-Feb-2024

Summary

Official Symbol
Slc25a1provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1provided by MGI
Primary source
MGI:MGI:1345283
See related
Ensembl:ENSMUSG00000003528 AllianceGenome:MGI:1345283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctp; Dgsj; Slc20a3; 1300019P08Rik; 2610100G11Rik
Summary
Predicted to enable citrate secondary active transmembrane transporter activity. Predicted to be involved in mitochondrial citrate transmembrane transport. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; clavicle; liver; and nervous system. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 548.0), subcutaneous fat pad adult (RPKM 316.7) and 16 other tissues See more
Orthologs
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Genomic context

See Slc25a1 in Genome Data Viewer
Location:
16 A3; 16 11.11 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17743075..17746083, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17925211..17928219, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene EST AA914427 Neighboring gene predicted gene, 56604 Neighboring gene STARR-seq mESC enhancer starr_40267 Neighboring gene predicted gene, 41427 Neighboring gene V-set pre-B cell surrogate light chain 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC47055

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables citrate secondary active transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables citrate secondary active transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables tricarboxylic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mitochondrial citrate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial citrate transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tricarboxylate transport protein, mitochondrial
Names
DiGeorge syndrome gene j
citrate transport protein
solute carrier family 25 member 1
tricarboxylate carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153150.2NP_694790.1  tricarboxylate transport protein, mitochondrial

    See identical proteins and their annotated locations for NP_694790.1

    Status: VALIDATED

    Source sequence(s)
    AK159289, BB698147, BU758271, CJ078562
    Consensus CDS
    CCDS28014.1
    UniProtKB/Swiss-Prot
    Q3TDH6, Q8JZU2
    Related
    ENSMUSP00000003622.9, ENSMUST00000003622.16
    Conserved Domains (1) summary
    pfam00153
    Location:24114
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17743075..17746083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)