Slc25a1 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a1provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1provided by MGI
Primary source: MGI:MGI:1345283
See related: Ensembl:ENSMUSG00000003528 AllianceGenome:MGI:1345283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctp; Dgsj; Slc20a3; 1300019P08Rik; 2610100G11Rik
Summary: Predicted to enable citrate secondary active transmembrane transporter activity. Predicted to be involved in mitochondrial citrate transmembrane transport. Located in mitochondrion. Is expressed in several structures, including adipose tissue; alimentary system; clavicle; liver; and nervous system. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 548.0), subcutaneous fat pad adult (RPKM 316.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.11 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17743075..17746083, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17925211..17928219, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

binding of PPRE of CiC promoter by PPARalpha and PPARgammain vivo
Title: Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a1 (e-PCR), detects polymorphism
- UniSTS:265747

Es2el (e-PCR), detects polymorphism
- UniSTS:260490

AI194714 (e-PCR)
- UniSTS:186060

NoName (e-PCR)
- UniSTS:547032

Slc25a1 (e-PCR), detects polymorphism
- UniSTS:547032

Homology

Homologs of the Slc25a1 gene: The Slc25a1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, C.elegans, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 339 organisms have orthologs with human gene Slc25a1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables citrate secondary active transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables citrate secondary active transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables tricarboxylic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial citrate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mitochondrial citrate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tricarboxylate transport protein, mitochondrial

Names: DiGeorge syndrome gene j; citrate transport protein; solute carrier family 25 member 1; tricarboxylate carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.