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Dgat1 diacylglycerol O-acyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 13350, updated on 1-Mar-2024

Summary

Official Symbol
Dgat1provided by MGI
Official Full Name
diacylglycerol O-acyltransferase 1provided by MGI
Primary source
MGI:MGI:1333825
See related
Ensembl:ENSMUSG00000022555 AllianceGenome:MGI:1333825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARAT; Dgat; D15Ertd23e
Summary
Enables 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Involved in several processes, including acylglycerol metabolic process; fatty acid homeostasis; and long-chain fatty-acyl-CoA metabolic process. Located in intracellular membrane-bounded organelle and membrane. Is integral component of membrane. Is expressed in several structures, including brain; genitourinary system; integument; liver; and yolk sac. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 359.0), small intestine adult (RPKM 242.2) and 9 other tissues See more
Orthologs
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Genomic context

See Dgat1 in Genome Data Viewer
Location:
15 D3; 15 35.99 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76386215..76396167, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76502012..76512021, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene block of proliferation 1 Neighboring gene scleraxis scleraxis bHLH transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E5490 Neighboring gene heat shock factor 1 Neighboring gene scratch family zinc finger 1 Neighboring gene predicted gene, 46533

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables diacylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diacylglycerol O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables diacylglycerol binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables retinol O-fatty-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in ketone body metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid storage IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-chain fatty-acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoacylglycerol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intestinal lipid absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vitamin A metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
diacylglycerol O-acyltransferase 1
Names
acyl-CoA retinol O-fatty-acyltransferase
diglyceride acyltransferase
NP_034176.1
XP_006520468.1
XP_017171915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010046.4NP_034176.1  diacylglycerol O-acyltransferase 1

    See identical proteins and their annotated locations for NP_034176.1

    Status: VALIDATED

    Source sequence(s)
    AC157566
    Consensus CDS
    CCDS27573.1
    UniProtKB/Swiss-Prot
    Q9D7Q5, Q9Z2A7
    UniProtKB/TrEMBL
    Q54AA6
    Related
    ENSMUSP00000023214.5, ENSMUST00000023214.11
    Conserved Domains (1) summary
    cl00738
    Location:79483
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RNA

  1. NR_177195.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157566

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76386215..76396167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520405.4XP_006520468.1  diacylglycerol O-acyltransferase 1 isoform X1

    Conserved Domains (1) summary
    cl00738
    Location:8418
    MBOAT; membrane-bound O-acyltransferase family
  2. XM_017316426.1XP_017171915.1  diacylglycerol O-acyltransferase 1 isoform X2

    Conserved Domains (1) summary
    cl00738
    Location:2312
    MBOAT; membrane-bound O-acyltransferase family