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DGAT1 diacylglycerol O-acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 8694, updated on 17-Dec-2019

Summary

Official Symbol
DGAT1provided by HGNC
Official Full Name
diacylglycerol O-acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:2843
See related
Ensembl:ENSG00000185000 MIM:604900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARAT; DGAT; ARGP1; DIAR7
Summary
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]
Expression
Broad expression in small intestine (RPKM 98.7), duodenum (RPKM 96.5) and 20 other tissues See more
Orthologs

Genomic context

See DGAT1 in Genome Data Viewer
Location:
8q24.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144314584..144326852, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145538246..145550582, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 7112 Neighboring gene BOP1 ribosomal biogenesis factor Neighboring gene scleraxis bHLH transcription factor Neighboring gene heat shock transcription factor 1 Neighboring gene microRNA 6848 Neighboring gene scratch family transcriptional repressor 1 Neighboring gene transmembrane protein 249 Neighboring gene F-box and leucine rich repeat protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2-acylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinol O-fatty-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
diacylglycerol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid homeostasis IEA
Inferred from Electronic Annotation
more info
 
lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
long-chain fatty-acyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
triglyceride metabolic process TAS
Traceable Author Statement
more info
PubMed 
very-low-density lipoprotein particle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
diacylglycerol O-acyltransferase 1
Names
ACAT related gene product 1
acyl coenzyme A:cholesterol acyltransferase related gene 1
acyl-CoA retinol O-fatty-acyltransferase
acyl-CoA:diacylglycerol acyltransferase
diacylglycerol O-acyltransferase homolog
diglyceride acyltransferase
NP_036211.2
XP_011515658.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034192.1 RefSeqGene

    Range
    5068..17336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012079.6NP_036211.2  diacylglycerol O-acyltransferase 1

    See identical proteins and their annotated locations for NP_036211.2

    Status: REVIEWED

    Source sequence(s)
    AC233992, BC023565
    Consensus CDS
    CCDS6420.1
    UniProtKB/Swiss-Prot
    O75907
    Related
    ENSP00000482264.1, ENST00000528718.6
    Conserved Domains (1) summary
    cl00738
    Location:70472
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144314584..144326852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517356.3XP_011515658.1  diacylglycerol O-acyltransferase 1 isoform X1

    Conserved Domains (1) summary
    cl00738
    Location:13415
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654716.1 Reference GRCh38.p13 PATCHES

    Range
    45187..57455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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