Format

Send to:

Choose Destination

ADM adrenomedullin [ Homo sapiens (human) ]

Gene ID: 133, updated on 24-Nov-2020

Summary

Official Symbol
ADMprovided by HGNC
Official Full Name
adrenomedullinprovided by HGNC
Primary source
HGNC:HGNC:259
See related
Ensembl:ENSG00000148926 MIM:103275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AM; PAMP
Summary
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Expression
Broad expression in placenta (RPKM 66.2), fat (RPKM 27.8) and 18 other tissues See more
Orthologs

Genomic context

See ADM in Genome Data Viewer
Location:
11p15.4
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (10305073..10307397)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10326642..10328923)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SET binding factor 2 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene uncharacterized LOC105376544 Neighboring gene uncharacterized LOC100130460 Neighboring gene VISTA enhancer hs2289 Neighboring gene RNA, U6atac small nuclear 33, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological, clinical and population relevance of 95 loci for blood lipids.
GeneReviews: Not available
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
GeneReviews: Not available
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
GeneReviews: Not available
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
GeneReviews: Not available
Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adrenomedullin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adrenomedullin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
amylin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
developmental growth IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
hormone secretion IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of progesterone biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of systemic arterial blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
regulation of the force of heart contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of urine volume IDA
Inferred from Direct Assay
more info
PubMed 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to starvation IEA
Inferred from Electronic Annotation
more info
 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
vascular associated smooth muscle cell development IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pro-adrenomedullin
Names
preproadrenomedullin
proadrenomedullin N-20 terminal peptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001124.3NP_001115.1  pro-adrenomedullin precursor

    See identical proteins and their annotated locations for NP_001115.1

    Status: REVIEWED

    Source sequence(s)
    BQ021632, D14874, HY105655
    Consensus CDS
    CCDS7801.1
    UniProtKB/Swiss-Prot
    P35318
    Related
    ENSP00000278175.5, ENST00000278175.10
    Conserved Domains (1) summary
    pfam00214
    Location:1151
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    10305073..10307397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center