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ADM adrenomedullin [ Homo sapiens (human) ]

Gene ID: 133, updated on 3-Jun-2018
Official Symbol
ADMprovided by HGNC
Official Full Name
adrenomedullinprovided by HGNC
Primary source
HGNC:HGNC:259
See related
Ensembl:ENSG00000148926 MIM:103275; Vega:OTTHUMG00000165907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AM; PAMP
Summary
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Expression
Broad expression in placenta (RPKM 66.2), fat (RPKM 27.8) and 18 other tissues See more
Orthologs
See ADM in Genome Data Viewer
Location:
11p15.4
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (10304980..10307402)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10326642..10328923)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SET binding factor 2 Neighboring gene glutamate-ammonia ligase pseudogene 2 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene uncharacterized LOC105376544 Neighboring gene uncharacterized LOC100130460 Neighboring gene RNA, U6atac small nuclear 33, pseudogene Neighboring gene adenosine monophosphate deaminase 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
NHGRI GWA Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
NHGRI GWA Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog
Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.
NHGRI GWA Catalog
  • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
    Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    HIF-1-alpha transcription factor network, organism-specific biosystem
    HIF-1-alpha transcription factor network
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adrenomedullin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adrenomedullin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
amylin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cAMP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
developmental growth IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
hormone secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
progesterone biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
regulation of the force of heart contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of urine volume IDA
Inferred from Direct Assay
more info
PubMed 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to starvation IEA
Inferred from Electronic Annotation
more info
 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spongiotrophoblast layer development IEA
Inferred from Electronic Annotation
more info
 
vascular smooth muscle cell development IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ADM
Names
preproadrenomedullin
proadrenomedullin N-20 terminal peptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001124.2NP_001115.1  ADM precursor

    See identical proteins and their annotated locations for NP_001115.1

    Status: REVIEWED

    Source sequence(s)
    BQ021632, D14874, HY105655
    Consensus CDS
    CCDS7801.1
    UniProtKB/Swiss-Prot
    P35318
    Related
    ENSP00000278175.5, OTTHUMP00000231484, ENST00000278175.9, OTTHUMT00000387004
    Conserved Domains (1) summary
    pfam00214
    Location:1151
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    10304980..10307402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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