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Adm adrenomedullin [ Mus musculus (house mouse) ]

Gene ID: 11535, updated on 18-Apr-2024

Summary

Official Symbol
Admprovided by MGI
Official Full Name
adrenomedullinprovided by MGI
Primary source
MGI:MGI:108058
See related
Ensembl:ENSMUSG00000030790 AllianceGenome:MGI:108058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AM
Summary
Predicted to enable adrenomedullin receptor binding activity. Involved in several processes, including negative regulation of vascular permeability; positive regulation of vasculogenesis; and vascular associated smooth muscle cell development. Acts upstream of or within several processes, including chordate embryonic development; heart development; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm and extracellular space. Is expressed in several structures, including cardiovascular system; extraembryonic component; gut; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 8.4), adrenal adult (RPKM 7.2) and 26 other tissues See more
Orthologs
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Genomic context

Location:
7 E3; 7 57.7 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110226864..110229027)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110627657..110629820)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SET binding factor 2 Neighboring gene predicted gene 10087 Neighboring gene ribosomal protein S8, pseudogene 1 pseudogene Neighboring gene predicted gene, 46027 Neighboring gene STARR-positive B cell enhancer ABC_E6586 Neighboring gene STARR-seq mESC enhancer starr_19827 Neighboring gene predicted gene 28863 Neighboring gene STARR-seq mESC enhancer starr_19828 Neighboring gene STARR-seq mESC enhancer starr_19829 Neighboring gene STARR-seq mESC enhancer starr_19831 Neighboring gene predicted gene, 21123 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adrenomedullin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adrenomedullin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenomedullin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adrenomedullin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spongiotrophoblast layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular associated smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009627.2NP_033757.1  pro-adrenomedullin precursor

    See identical proteins and their annotated locations for NP_033757.1

    Status: VALIDATED

    Source sequence(s)
    AC154911, AK144181
    Consensus CDS
    CCDS21745.1
    UniProtKB/Swiss-Prot
    P97297, P97453, Q6GTK2
    Related
    ENSMUSP00000033054.9, ENSMUST00000033054.10
    Conserved Domains (1) summary
    pfam00214
    Location:1149
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    110226864..110229027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)