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ARL9 ADP ribosylation factor like GTPase 9 [ Homo sapiens (human) ]

Gene ID: 132946, updated on 6-Sep-2021

Summary

Official Symbol
ARL9provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 9provided by HGNC
Primary source
HGNC:HGNC:23592
See related
Ensembl:ENSG00000196503 MIM:612405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008]
Expression
Biased expression in testis (RPKM 1.5), skin (RPKM 0.3) and 10 other tissues See more
Orthologs
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Genomic context

See ARL9 in Genome Data Viewer
Location:
4q12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (56505209..56524453)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (57371375..57390619)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene signal recognition particle 72 Neighboring gene uncharacterized LOC105377665 Neighboring gene theg spermatid protein like Neighboring gene glycine decarboxylase pseudogene 1 Neighboring gene HOP homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ADP-ribosylation factor-like 9 (ARL9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 9
Names
ADP-ribosylation factor-like 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363794.2NP_001350723.1  ADP-ribosylation factor-like protein 9 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108215, AC114766
    Consensus CDS
    CCDS87224.1
    Related
    ENSP00000492671.3, ENST00000640821.3
    Conserved Domains (1) summary
    cd04162
    Location:98263
    Arl9_Arfrp2_like; Arf-like 9 (Arl9)/Arfrp2-like GTPase
  2. NM_206919.3NP_996802.1  ADP-ribosylation factor-like protein 9 isoform 2

    See identical proteins and their annotated locations for NP_996802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC108215, AC114766
    Consensus CDS
    CCDS59474.1
    UniProtKB/Swiss-Prot
    Q6T311
    Related
    ENSP00000353210.2, ENST00000360096.3
    Conserved Domains (1) summary
    cl21455
    Location:1121
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    56505209..56524453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714036.4XP_006714099.1  ADP-ribosylation factor-like protein 9 isoform X2

    See identical proteins and their annotated locations for XP_006714099.1

    UniProtKB/Swiss-Prot
    Q6T311
    Conserved Domains (1) summary
    cl21455
    Location:1121
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005265720.4XP_005265777.1  ADP-ribosylation factor-like protein 9 isoform X2

    See identical proteins and their annotated locations for XP_005265777.1

    UniProtKB/Swiss-Prot
    Q6T311
    Conserved Domains (1) summary
    cl21455
    Location:1121
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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