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C4orf33 chromosome 4 open reading frame 33 [ Homo sapiens (human) ]

Gene ID: 132321, updated on 11-Sep-2019

Summary

Official Symbol
C4orf33provided by HGNC
Official Full Name
chromosome 4 open reading frame 33provided by HGNC
Primary source
HGNC:HGNC:27025
See related
Ensembl:ENSG00000151470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in colon (RPKM 3.9), duodenum (RPKM 3.8) and 25 other tissues See more
Orthologs

Genomic context

See C4orf33 in Genome Data Viewer
Location:
4q28.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (129093691..129116637)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (130014829..130034487)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927259 Neighboring gene jade family PHD finger 1 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene chromosome 2 open reading frame 27B pseudogene Neighboring gene zinc finger SWIM-type containing 5 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chromosome 4 open reading frame 33 (C4orf33) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33703

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099783.2NP_001093253.1  UPF0462 protein C4orf33

    See identical proteins and their annotated locations for NP_001093253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093826, BC032582, BE566349, BQ549846, BU783470, CN483524
    Consensus CDS
    CCDS3741.1
    UniProtKB/Swiss-Prot
    Q8N1A6
    Related
    ENSP00000401090.1, ENST00000425929.6
    Conserved Domains (1) summary
    cl14783
    Location:42171
    DOMON_like; Domon-like ligand-binding domains
  2. NM_173487.3NP_775758.2  UPF0462 protein C4orf33

    See identical proteins and their annotated locations for NP_775758.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093826, BC032582, BP871612, BQ549846, BU783470
    Consensus CDS
    CCDS3741.1
    UniProtKB/Swiss-Prot
    Q8N1A6
    Related
    ENSP00000281146.4, ENST00000281146.9
    Conserved Domains (1) summary
    cl14783
    Location:42171
    DOMON_like; Domon-like ligand-binding domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    129093691..129116637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007724.1XP_016863213.1  UPF0462 protein C4orf33 isoform X4

    Related
    ENSP00000427406.1, ENST00000502887.5
    Conserved Domains (1) summary
    cl14783
    Location:4294
    DOMON_like; Domon-like ligand-binding domains
  2. XM_005262734.5XP_005262791.1  UPF0462 protein C4orf33 isoform X2

    See identical proteins and their annotated locations for XP_005262791.1

    UniProtKB/Swiss-Prot
    Q8N1A6
    Conserved Domains (1) summary
    cl14783
    Location:42171
    DOMON_like; Domon-like ligand-binding domains
  3. XM_017007722.1XP_016863211.1  UPF0462 protein C4orf33 isoform X1

  4. XM_017007723.1XP_016863212.1  UPF0462 protein C4orf33 isoform X3

RNA

  1. XR_001741132.1 RNA Sequence

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