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Dhx9 DExH-box helicase 9 [ Mus musculus (house mouse) ]

Gene ID: 13211, updated on 12-Feb-2024

Summary

Official Symbol
Dhx9provided by MGI
Official Full Name
DExH-box helicase 9provided by MGI
Primary source
MGI:MGI:108177
See related
Ensembl:ENSMUSG00000042699 AllianceGenome:MGI:108177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RHA; Ddx9; HEL-5; NDHII; mHEL-5
Summary
Enables regulatory region RNA binding activity. Involved in positive regulation of interleukin-18 production; pyroptosis; and regulation of defense response. Acts upstream of or within cellular response to heat and circadian rhythm. Located in nucleolus. Is expressed in several structures, including alimentary system; central nervous system; lung; sensory organ; and vibrissa. Orthologous to human DHX9 (DExH-box helicase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 71.6), CNS E14 (RPKM 55.5) and 21 other tissues See more
Orthologs
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Genomic context

See Dhx9 in Genome Data Viewer
Location:
1 G3; 1 65.37 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153331506..153363464, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153455756..153487688, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Riken cDNA E330020D12 gene Neighboring gene STARR-positive B cell enhancer ABC_E5821 Neighboring gene STARR-positive B cell enhancer ABC_E5822 Neighboring gene Shc SH2-domain binding protein 1-like Neighboring gene predicted gene, 25588 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155334650-155334951 Neighboring gene STARR-positive B cell enhancer ABC_E7758 Neighboring gene STARR-seq mESC enhancer starr_02698 Neighboring gene STARR-seq mESC enhancer starr_02701 Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene STARR-seq mESC enhancer starr_02703 Neighboring gene STARR-seq mESC enhancer starr_02704 Neighboring gene STARR-seq mESC enhancer starr_02705 Neighboring gene predicted gene 6652

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90954

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3'-5' DNA/RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3'-5' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA replication origin binding ISO
Inferred from Sequence Orthology
more info
 
enables RISC complex binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside triphosphate diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables polysome binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables regulatory region RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables regulatory region RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables siRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
enables triplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA-templated transcription termination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in G-quadruplex DNA unwinding ISO
Inferred from Sequence Orthology
more info
 
involved_in RISC complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA secondary structure unwinding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-18 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral translation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
 
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
 
part_of RISC-loading complex ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perichromatin fibrils ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase A
Names
D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 9
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 9
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
DEAH box protein 9
RNA helicase A
leukophysin
nuclear DNA helicase II
NP_001392438.1
NP_031868.2
XP_030102263.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405509.1NP_001392438.1  ATP-dependent RNA helicase A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC098709, AC099712
    UniProtKB/Swiss-Prot
    O35931, O54703, O70133, Q5FWY1, Q6R5F7, Q9CSA2
    UniProtKB/TrEMBL
    E9QNN1
    Related
    ENSMUSP00000038135.6, ENSMUST00000042141.12
  2. NM_007842.3NP_031868.2  ATP-dependent RNA helicase A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC098709, AC099712
    Consensus CDS
    CCDS78706.1
    UniProtKB/Swiss-Prot
    O35931, O54703, O70133, Q5FWY1, Q6R5F7, Q9CSA2
    UniProtKB/TrEMBL
    A0A087WPL5
    Related
    ENSMUSP00000139825.2, ENSMUST00000186380.7
    Conserved Domains (6) summary
    smart00358
    Location:569
    DSRM; Double-stranded RNA binding motif
    smart00847
    Location:840921
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:3361054
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:407548
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:637770
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:9611075
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. NR_175951.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098709, AC099712
  2. NR_175952.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098709, AC099712

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    153331506..153363464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246403.2XP_030102263.1  ATP-dependent RNA helicase A isoform X2

    UniProtKB/Swiss-Prot
    O35931, O54703, O70133, Q5FWY1, Q6R5F7, Q9CSA2
    Conserved Domains (3) summary
    COG1643
    Location:120838
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd17972
    Location:116349
    DEXHc_DHX9; DEXH-box helicase domain of DEAH-box helicase 9
    cd19855
    Location:138
    DSRM_DHX9_rpt2; second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins