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Ddit3 DNA-damage inducible transcript 3 [ Mus musculus (house mouse) ]

Gene ID: 13198, updated on 18-Apr-2024

Summary

Official Symbol
Ddit3provided by MGI
Official Full Name
DNA-damage inducible transcript 3provided by MGI
Primary source
MGI:MGI:109247
See related
Ensembl:ENSMUSG00000025408 AllianceGenome:MGI:109247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
chop; CHOP10; CHOP-10; gadd153; AltDDIT3
Summary
Enables several functions, including cAMP response element binding protein binding activity; protein heterodimerization activity; and transcription regulator inhibitor activity. Involved in several processes, including blood vessel maturation; intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within ER overload response; negative regulation of fat cell differentiation; and sensory perception of sound. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.2), ovary adult (RPKM 9.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 D3; 10 74.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127126662..127132160)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127290793..127296291)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 5A Neighboring gene STARR-positive B cell enhancer ABC_E9810 Neighboring gene predicted gene, 40800 Neighboring gene dynactin 2 Neighboring gene STARR-positive B cell enhancer ABC_E10652 Neighboring gene STARR-positive B cell enhancer ABC_E1410 Neighboring gene STARR-positive B cell enhancer ABC_E6939 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene methionine-tRNA synthetase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126748829-126749012 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10653 Neighboring gene Rho GTPase activating protein 9 Neighboring gene GLI-Kruppel family member GLI1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP response element binding protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP response element binding protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription regulator activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription regulator inhibitor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ER overload response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ER overload response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ER overload response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in anterior/posterior axis specification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization to mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to nitrosative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of determination of dorsal identity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy in response to ER overload ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to platelet-derived growth factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CHOP-ATF3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CHOP-ATF3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of CHOP-ATF4 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CHOP-ATF4 complex ISO
Inferred from Sequence Orthology
more info
 
part_of CHOP-C/EBP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CHOP-C/EBP complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of CHOP-C/EBP complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA damage-inducible transcript 3 protein
Names
C/EBP homoologous protein 10
C/EBP zeta
CCAAT/enhancer-binding protein homologous protein
DDIT-3
alternative DDIT3 proteins
c/EBP-homologous protein 10
growth arrest and DNA-damage-inducible protein GADD153

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290183.2NP_001277112.1  DNA damage-inducible transcript 3 protein

    See identical proteins and their annotated locations for NP_001277112.1

    Status: VALIDATED

    Source sequence(s)
    AC144852
    Consensus CDS
    CCDS24236.1
    UniProtKB/Swiss-Prot
    P35639, Q91YW9
    UniProtKB/TrEMBL
    Q3V405
    Related
    ENSMUSP00000118339.2, ENSMUST00000139091.2
    Conserved Domains (2) summary
    smart00338
    Location:100160
    BRLZ; basic region leucin zipper
    cd14686
    Location:102152
    bZIP; coiled coil [structural motif]
  2. NM_001428453.1NP_001415382.1  DNA damage-inducible transcript 3 protein

    Status: VALIDATED

    Source sequence(s)
    AC144852
    UniProtKB/Swiss-Prot
    P35639, Q91YW9
  3. NM_001428454.1NP_001415383.1  DNA damage-inducible transcript 3 protein

    Status: VALIDATED

    Source sequence(s)
    AC144852
    UniProtKB/Swiss-Prot
    P35639, Q91YW9
  4. NM_007837.5NP_031863.3  DNA damage-inducible transcript 3 protein

    See identical proteins and their annotated locations for NP_031863.3

    Status: VALIDATED

    Source sequence(s)
    AC144852
    Consensus CDS
    CCDS24236.1
    UniProtKB/Swiss-Prot
    P35639, Q91YW9
    UniProtKB/TrEMBL
    Q3V405
    Related
    ENSMUSP00000026475.9, ENSMUST00000026475.15
    Conserved Domains (2) summary
    smart00338
    Location:100160
    BRLZ; basic region leucin zipper
    cd14686
    Location:102152
    bZIP; coiled coil [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127126662..127132160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513197.4XP_006513260.1  DNA damage-inducible transcript 3 protein isoform X2

    Conserved Domains (2) summary
    smart00338
    Location:100160
    BRLZ; basic region leucin zipper
    cd14686
    Location:102152
    bZIP; coiled coil [structural motif]
  2. XM_030244867.1XP_030100727.1  DNA damage-inducible transcript 3 protein isoform X1

    UniProtKB/TrEMBL
    Q3V405
    Conserved Domains (2) summary
    smart00338
    Location:114174
    BRLZ; basic region leucin zipper
    cd14686
    Location:116166
    bZIP; coiled coil [structural motif]