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DDIT3 DNA damage inducible transcript 3 [ Homo sapiens (human) ]

Gene ID: 1649, updated on 8-Jul-2018
Official Symbol
DDIT3provided by HGNC
Official Full Name
DNA damage inducible transcript 3provided by HGNC
Primary source
HGNC:HGNC:2726
See related
Ensembl:ENSG00000175197 MIM:126337; Vega:OTTHUMG00000170046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHOP; CEBPZ; CHOP10; CHOP-10; GADD153; C/EBPzeta
Summary
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
Expression
Broad expression in thyroid (RPKM 74.2), bone marrow (RPKM 47.3) and 24 other tissues See more
Orthologs
See DDIT3 in Genome Data Viewer
Location:
12q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (57516588..57520517, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57910371..57914300, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GLI family zinc finger 1 Neighboring gene Rho GTPase activating protein 9 Neighboring gene methionyl-tRNA synthetase Neighboring gene microRNA 6758 Neighboring gene microRNA 616 Neighboring gene methyl-CpG binding domain protein 6 Neighboring gene dynactin subunit 2 Neighboring gene kinesin family member 5A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env gp120 upregulates DDIT3 (CHOP) in SVGA cells and human fetal astrocytes via IRE1a, JNK, and AP-1 PubMed
Tat tat HIV-1 Tat induces endoplasmic reticulum (ER) stress response proteins CASP12 (Caspase 12), DDIT3 (CHOP), ROS1, ERN-1 (p-IRE1), EIF2AK3 (p-PERK), and ATF6 in human brain microvascular endothelial cells (HBMECs) PubMed
tat HIV-1 Tat is dependent on DDIT3 (CHOP) to induce apoptosis in Human Brain Microvascular Endothelial Cells (HBMECs) as shown through DDIT3 siRNA knockdown PubMed
tat Expression of Rad51 enhances basal- and HIV-1 Tat-induced transcription of the HIV-1 LTR promoter; this event requires cooperativity from the C/EBP family of transcription factors including C/EBPbeta and C/EBPbeta homologous protein (CHOP) PubMed

Go to the HIV-1, Human Interaction Database

  • ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    ATF-2 transcription factor network, organism-specific biosystem
    ATF-2 transcription factor network
  • ATF4 activates genes, organism-specific biosystem (from REACTOME)
    ATF4 activates genes, organism-specific biosystemATF4 is a transcription factor and activates expression of IL-8, MCP1, IGFBP-1, CHOP, HERP1 and ATF3.
  • ATF6 (ATF6-alpha) activates chaperone genes, organism-specific biosystem (from REACTOME)
    ATF6 (ATF6-alpha) activates chaperone genes, organism-specific biosystemThe N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription...
  • ATF6 (ATF6-alpha) activates chaperones, organism-specific biosystem (from REACTOME)
    ATF6 (ATF6-alpha) activates chaperones, organism-specific biosystemATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions ...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • PERK regulates gene expression, organism-specific biosystem (from REACTOME)
    PERK regulates gene expression, organism-specific biosystemPERK (EIF2AK3) is a single-pass transmembrane protein located in the endoplasmic reticulum (ER) membrane such that the N-terminus of PERK is luminal and the C-terminus is cytosolic. PERK is maintaine...
  • Photodynamic therapy-induced unfolded protein response, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an...
  • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
    Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
    Signaling mediated by p38-alpha and p38-beta
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
  • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Validated targets of C-MYC transcriptional repression, organism-specific biosystem
    Validated targets of C-MYC transcriptional repression
  • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC4154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IC
Inferred by Curator
more info
PubMed 
DNA-binding transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
cAMP response element binding protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
leucine zipper domain binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
protein heterodimerization activity TAS
Traceable Author Statement
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IC
Inferred by Curator
more info
PubMed 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ATF6-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
ER overload response IEA
Inferred from Electronic Annotation
more info
 
PERK-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus TAS
Traceable Author Statement
more info
PubMed 
establishment of protein localization to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to nitrosative stress IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of CREB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of determination of dorsal identity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IC
Inferred by Curator
more info
PubMed 
positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process IC
Inferred by Curator
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA-templated transcription in response to stress TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription involved in anterior/posterior axis specification ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
response to starvation IEA
Inferred from Electronic Annotation
more info
 
response to unfolded protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
CHOP-ATF3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CHOP-ATF3 complex IDA
Inferred from Direct Assay
more info
PubMed 
CHOP-ATF4 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CHOP-ATF4 complex IDA
Inferred from Direct Assay
more info
PubMed 
CHOP-ATF4 complex IPI
Inferred from Physical Interaction
more info
PubMed 
CHOP-C/EBP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CHOP-C/EBP complex ISS
Inferred from Sequence or Structural Similarity
more info
 
CHOP-C/EBP complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with transcription factor AP-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
DNA damage-inducible transcript 3 protein
Names
C/EBP zeta
CCAAT/enhancer-binding protein homologous protein
c/EBP-homologous protein 10
growth arrest and DNA damage-inducible protein GADD153

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027674.1 RefSeqGene

    Range
    5001..8930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195053.1NP_001181982.1  DNA damage-inducible transcript 3 protein isoform 1

    See identical proteins and their annotated locations for NP_001181982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AY461580, BM464290
    Consensus CDS
    CCDS55838.1
    UniProtKB/Swiss-Prot
    P35638
    Related
    ENSP00000448665.1, OTTHUMP00000242753, ENST00000551116.5, OTTHUMT00000407135
    Conserved Domains (3) summary
    smart00338
    Location:119182
    BRLZ; basic region leucin zipper
    cd14686
    Location:125176
    bZIP; coiled coil [structural motif]
    pfam02724
    Location:40148
    CDC45; CDC45-like protein
  2. NM_001195054.1NP_001181983.1  DNA damage-inducible transcript 3 protein isoform 1

    See identical proteins and their annotated locations for NP_001181983.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform 1.
    Source sequence(s)
    AY461580, BM464290, BU664077
    Consensus CDS
    CCDS55838.1
    UniProtKB/Swiss-Prot
    P35638
    Conserved Domains (3) summary
    smart00338
    Location:119182
    BRLZ; basic region leucin zipper
    cd14686
    Location:125176
    bZIP; coiled coil [structural motif]
    pfam02724
    Location:40148
    CDC45; CDC45-like protein
  3. NM_001195055.1NP_001181984.1  DNA damage-inducible transcript 3 protein isoform 1

    See identical proteins and their annotated locations for NP_001181984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform 1.
    Source sequence(s)
    AA054097, AY461580, BM464290
    Consensus CDS
    CCDS55838.1
    UniProtKB/Swiss-Prot
    P35638
    Conserved Domains (3) summary
    smart00338
    Location:119182
    BRLZ; basic region leucin zipper
    cd14686
    Location:125176
    bZIP; coiled coil [structural motif]
    pfam02724
    Location:40148
    CDC45; CDC45-like protein
  4. NM_001195056.1NP_001181985.1  DNA damage-inducible transcript 3 protein isoform 1

    See identical proteins and their annotated locations for NP_001181985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an additional segment in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform 1.
    Source sequence(s)
    AK316581, AY461580, BM464290
    Consensus CDS
    CCDS55838.1
    UniProtKB/TrEMBL
    Q53YD1
    Related
    ENSP00000447803.1, OTTHUMP00000242755, ENST00000552740.5, OTTHUMT00000407138
    Conserved Domains (3) summary
    smart00338
    Location:119182
    BRLZ; basic region leucin zipper
    cd14686
    Location:125176
    bZIP; coiled coil [structural motif]
    pfam02724
    Location:40148
    CDC45; CDC45-like protein
  5. NM_001195057.1NP_001181986.1  DNA damage-inducible transcript 3 protein isoform 2

    See identical proteins and their annotated locations for NP_001181986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an internal segment in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AY461580, BM464290, CN482428
    Consensus CDS
    CCDS8943.1
    UniProtKB/Swiss-Prot
    P35638
    UniProtKB/TrEMBL
    Q53YD1
    Related
    ENSP00000447188.1, OTTHUMP00000242752, ENST00000547303.5, OTTHUMT00000407134
    Conserved Domains (3) summary
    smart00338
    Location:96159
    BRLZ; basic region leucin zipper
    cd14686
    Location:102153
    bZIP; coiled coil [structural motif]
    pfam02724
    Location:17125
    CDC45; CDC45-like protein
  6. NM_004083.5NP_004074.2  DNA damage-inducible transcript 3 protein isoform 2

    See identical proteins and their annotated locations for NP_004074.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AY461580, BC003637, BM464290
    Consensus CDS
    CCDS8943.1
    UniProtKB/Swiss-Prot
    P35638
    UniProtKB/TrEMBL
    Q53YD1
    Related
    ENSP00000340671.3, OTTHUMP00000242754, ENST00000346473.7, OTTHUMT00000407137
    Conserved Domains (3) summary
    smart00338
    Location:96159
    BRLZ; basic region leucin zipper
    cd14686
    Location:102153
    bZIP; coiled coil [structural motif]
    pfam02724
    Location:17125
    CDC45; CDC45-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    57516588..57520517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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