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METTL6 methyltransferase like 6 [ Homo sapiens (human) ]

Gene ID: 131965, updated on 24-Nov-2020

Summary

Official Symbol
METTL6provided by HGNC
Official Full Name
methyltransferase like 6provided by HGNC
Primary source
HGNC:HGNC:28343
See related
Ensembl:ENSG00000206562 MIM:618903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 1.5), brain (RPKM 1.4) and 25 other tissues See more
Orthologs

Genomic context

See METTL6 in Genome Data Viewer
Location:
3p25.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (15381275..15427580, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15422782..15469054, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SH3 domain binding protein 5 Neighboring gene RNA, U6 small nuclear 454, pseudogene Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 7 Neighboring gene RNA, U6 small nuclear 1024, pseudogene Neighboring gene ELL associated factor 1 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene microRNA 4270

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tRNA (cytosine-3-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
tRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
tRNA N(3)-methylcytidine methyltransferase METTL6
Names
methyltransferase-like protein 6
NP_001288719.1
NP_001288720.1
NP_001288721.1
NP_001317591.1
NP_689609.2
XP_005264924.1
XP_006713033.1
XP_006713035.1
XP_011531659.1
XP_016861207.1
XP_016861208.1
XP_016861211.1
XP_016861212.1
XP_016861213.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301790.2NP_001288719.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 2

    See identical proteins and their annotated locations for NP_001288719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC027125, AK293370, BG701912, CX872865, Z44406
    Consensus CDS
    CCDS77706.1
    UniProtKB/TrEMBL
    B4DDX3
    Related
    ENSP00000410726.2, ENST00000450816.6
    Conserved Domains (1) summary
    cd02440
    Location:70142
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001301791.2NP_001288720.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple coding region differences, including an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC027125, BG701912, BU183521, CA430635
    Conserved Domains (1) summary
    pfam08242
    Location:84178
    Methyltransf_12; Methyltransferase domain
  3. NM_001301792.2NP_001288721.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC027125, BC022400, BG701912, BI913767, CX872865, Z44406
    UniProtKB/Swiss-Prot
    Q8TCB7
    Conserved Domains (1) summary
    pfam08242
    Location:84177
    Methyltransf_12; Methyltransferase domain
  4. NM_001330662.2NP_001317591.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC027125, BX114702
    Consensus CDS
    CCDS87051.1
    UniProtKB/Swiss-Prot
    Q8TCB7
    Related
    ENSP00000373299.5, ENST00000383789.9
    Conserved Domains (1) summary
    pfam08242
    Location:84178
    Methyltransf_12; Methyltransferase domain
  5. NM_152396.4NP_689609.2  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

    See identical proteins and their annotated locations for NP_689609.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC027125, BC022400, BG701912, CX872865, Z44406
    Consensus CDS
    CCDS43056.1
    UniProtKB/Swiss-Prot
    Q8TCB7
    Related
    ENSP00000373300.3, ENST00000383790.7
    Conserved Domains (1) summary
    pfam08242
    Location:84182
    Methyltransf_12; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    15381275..15427580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005719.1XP_016861208.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X2

    UniProtKB/TrEMBL
    B4DDX3
    Conserved Domains (1) summary
    cd02440
    Location:70142
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017005723.1XP_016861212.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X6

    Conserved Domains (1) summary
    cd02440
    Location:70132
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_005264867.4XP_005264924.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

    See identical proteins and their annotated locations for XP_005264924.1

    UniProtKB/Swiss-Prot
    Q8TCB7
    Related
    ENSP00000407613.1, ENST00000443029.5
    Conserved Domains (1) summary
    pfam08242
    Location:84182
    Methyltransf_12; Methyltransferase domain
  4. XM_006712972.4XP_006713035.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

    Conserved Domains (1) summary
    pfam08242
    Location:84178
    Methyltransf_12; Methyltransferase domain
  5. XM_017005722.2XP_016861211.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X5

    Conserved Domains (1) summary
    pfam08242
    Location:84177
    Methyltransf_12; Methyltransferase domain
  6. XM_017005718.2XP_016861207.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

    UniProtKB/Swiss-Prot
    Q8TCB7
    Conserved Domains (1) summary
    pfam08242
    Location:84182
    Methyltransf_12; Methyltransferase domain
  7. XM_006712970.4XP_006713033.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

    See identical proteins and their annotated locations for XP_006713033.1

    UniProtKB/Swiss-Prot
    Q8TCB7
    Conserved Domains (1) summary
    pfam08242
    Location:84182
    Methyltransf_12; Methyltransferase domain
  8. XM_011533357.3XP_011531659.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X4

    Conserved Domains (1) summary
    pfam08242
    Location:84178
    Methyltransf_12; Methyltransferase domain
  9. XM_017005724.2XP_016861213.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X7

    Conserved Domains (1) summary
    pfam08242
    Location:84178
    Methyltransf_12; Methyltransferase domain

RNA

  1. XR_001740018.2 RNA Sequence

  2. XR_001740019.2 RNA Sequence

  3. XR_940377.3 RNA Sequence

  4. XR_002959491.1 RNA Sequence

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