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Dbi diazepam binding inhibitor [ Mus musculus (house mouse) ]

Gene ID: 13167, updated on 8-Feb-2024

Summary

Official Symbol
Dbiprovided by MGI
Official Full Name
diazepam binding inhibitorprovided by MGI
Primary source
MGI:MGI:94865
See related
Ensembl:ENSMUSG00000026385 AllianceGenome:MGI:94865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EP; Acbp; ACBD1; endozepine
Summary
Predicted to enable benzodiazepine receptor binding activity; identical protein binding activity; and long-chain fatty acyl-CoA binding activity. Acts upstream of or within several processes, including behavioral fear response; lateral ventricle development; and long-term synaptic potentiation. Located in mitochondrion. Is expressed in brain; cerebral cortex subventricular zone; cerebral cortex ventricular layer; early conceptus; and neocortex. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 440.8), subcutaneous fat pad adult (RPKM 390.0) and 26 other tissues See more
Orthologs
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Genomic context

See Dbi in Genome Data Viewer
Location:
1 E2.3; 1 52.65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (120041010..120048826, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120113280..120121096, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10029 Neighboring gene predicted gene, 41937 Neighboring gene predicted gene, 41938 Neighboring gene RIKEN cDNA 3110009E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E4342 Neighboring gene STARR-positive B cell enhancer mm9_chr1:122050580-122050881 Neighboring gene STARR-positive B cell enhancer mm9_chr1:122093817-122094118 Neighboring gene STARR-seq mESC enhancer starr_02054 Neighboring gene STEAP family member 3 Neighboring gene STARR-seq mESC enhancer starr_02055 Neighboring gene predicted gene, 53581 Neighboring gene STARR-seq mESC enhancer starr_02056 Neighboring gene complement component 1, q subcomponent-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables benzodiazepine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral ventricle development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within learning or memory IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein lipidation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in contractile fiber ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
part_of protein-lipid complex ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-CoA-binding protein
Names
diazepam binding inhibitor, splice form 1b
NP_001033088.1
NP_031856.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037999.2NP_001033088.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001033088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC139867
    Consensus CDS
    CCDS15231.1
    UniProtKB/TrEMBL
    F6ZM12, Q4VWZ5
    Related
    ENSMUSP00000114705.3, ENSMUST00000151708.3
    Conserved Domains (1) summary
    cd00435
    Location:52134
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  2. NM_007830.4NP_031856.1  acyl-CoA-binding protein isoform 2

    See identical proteins and their annotated locations for NP_031856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK020692, AV001592, CJ183794
    Consensus CDS
    CCDS15230.1
    UniProtKB/Swiss-Prot
    P31786
    UniProtKB/TrEMBL
    Q3ULV8, Q548W7
    Related
    ENSMUSP00000027634.7, ENSMUST00000027634.13
    Conserved Domains (1) summary
    cd00435
    Location:286
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    120041010..120048826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)