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Dbi diazepam binding inhibitor [ Mus musculus (house mouse) ]

Gene ID: 13167, updated on 30-Mar-2019

Summary

Official Symbol
Dbiprovided by MGI
Official Full Name
diazepam binding inhibitorprovided by MGI
Primary source
MGI:MGI:94865
See related
Ensembl:ENSMUSG00000026385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EP; Acbp; ACBD1; endozepine
Expression
Ubiquitous expression in liver E18 (RPKM 440.8), subcutaneous fat pad adult (RPKM 390.0) and 26 other tissues See more
Orthologs

Genomic context

See Dbi in Genome Data Viewer
Location:
1; 1 E2.3
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (120113280..120121096, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (122009857..122017673, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41937 Neighboring gene predicted gene, 41938 Neighboring gene RIKEN cDNA 3110009E18 gene Neighboring gene STEAP family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
benzodiazepine receptor binding ISO
Inferred from Sequence Orthology
more info
 
fatty-acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
behavioral fear response IDA
Inferred from Direct Assay
more info
PubMed 
glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lateral ventricle development IDA
Inferred from Direct Assay
more info
PubMed 
learning or memory IDA
Inferred from Direct Assay
more info
PubMed 
long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine acyl-chain remodeling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
contractile fiber ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-CoA-binding protein
Names
diazepam binding inhibitor, splice form 1b
NP_001033088.1
NP_031856.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037999.2NP_001033088.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001033088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC139867
    Consensus CDS
    CCDS15231.1
    UniProtKB/TrEMBL
    Q4VWZ5
    Related
    ENSMUSP00000114705.2, ENSMUST00000151708.2
    Conserved Domains (1) summary
    cd00435
    Location:52134
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  2. NM_007830.4NP_031856.1  acyl-CoA-binding protein isoform 2

    See identical proteins and their annotated locations for NP_031856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK020692, AV001592, CJ183794
    Consensus CDS
    CCDS15230.1
    UniProtKB/Swiss-Prot
    P31786
    UniProtKB/TrEMBL
    Q548W7
    Related
    ENSMUSP00000027634.6, ENSMUST00000027634.12
    Conserved Domains (1) summary
    cd00435
    Location:286
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    120113280..120121096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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