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DBI diazepam binding inhibitor, acyl-CoA binding protein [ Homo sapiens (human) ]

Gene ID: 1622, updated on 13-Feb-2019

Summary

Official Symbol
DBIprovided by HGNC
Official Full Name
diazepam binding inhibitor, acyl-CoA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:2690
See related
Ensembl:ENSG00000155368 MIM:125950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP; ACBP; ACBD1; CCK-RP
Summary
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 97.8), liver (RPKM 93.2) and 25 other tissues See more
Orthologs

Genomic context

See DBI in Genome Data Viewer
Location:
2q14.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (119366924..119372551)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120124504..120130122)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene STEAP3 metalloreductase Neighboring gene uncharacterized LOC105373581 Neighboring gene chromosome 2 open reading frame 76 Neighboring gene transmembrane protein 37 Neighboring gene secretin receptor Neighboring gene uncharacterized LOC107105282 Neighboring gene VISTA enhancer hs1941

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

  • Fatty Acyl-CoA Biosynthesis, organism-specific biosystem (from REACTOME)
    Fatty Acyl-CoA Biosynthesis, organism-specific biosystemFatty acyl-CoA biosynthesis involves following steps: -Palmitate synthesis catalyzed by Acetyl-CoA carboxylase and Fatty acid synthase-Conversion of palmitic acid to long chain fatty acids and-Conver...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPAR Alpha Pathway, organism-specific biosystem (from WikiPathways)
    PPAR Alpha Pathway, organism-specific biosystemPPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc.
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystem (from WikiPathways)
    Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Triglyceride Biosynthesis, organism-specific biosystem (from REACTOME)
    Triglyceride Biosynthesis, organism-specific biosystemThe overall process of triglyceride (triacylglycerol) biosynthesis consists of four biochemical pathways: fatty acyl-CoA biosynthesis, conversion of fatty acyl-CoA to phosphatidic acid, conversion of...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70414

Gene Ontology Provided by GOA

Function Evidence Code Pubs
benzodiazepine receptor binding TAS
Traceable Author Statement
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
acyl-CoA-binding protein
Names
GABA receptor modulator
acyl coenzyme A binding protein
acyl-Coenzyme A binding domain containing 1
cholecystokinin-releasing peptide, trypsin-sensitive
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
diazepam-binding inhibitor
endozepine
epididymis secretory sperm binding protein
NP_001073331.1
NP_001073332.1
NP_001171488.1
NP_001171512.1
NP_001171513.1
NP_001171514.1
NP_001269562.1
NP_001269563.1
NP_001269564.1
NP_001269565.1
NP_001339361.1
NP_065438.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079862.2NP_001073331.1  acyl-CoA-binding protein isoform 3

    See identical proteins and their annotated locations for NP_001073331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as 1a) lacks an in-frame exon in the 5' coding region, as compared to variant 5. The resulting isoform (3) lacks an internal segment in the N-terminal region, as compared to isoform 5.
    Source sequence(s)
    BM768076, BU599304
    Consensus CDS
    CCDS42740.1
    UniProtKB/Swiss-Prot
    P07108
    Related
    ENSP00000348116.3, ENST00000355857.7
    Conserved Domains (1) summary
    cd00435
    Location:286
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  2. NM_001079863.1NP_001073332.1  acyl-CoA-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001073332.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as 1c) differs in the 5' UTR and 5' coding region, as compared to variant 5. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 5.
    Source sequence(s)
    AM000001, BP318721, DA226476
    Consensus CDS
    CCDS42741.1
    UniProtKB/Swiss-Prot
    P07108
    Related
    ENSP00000376815.2, ENST00000393103.2
    Conserved Domains (1) summary
    cd00435
    Location:587
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  3. NM_001178017.1NP_001171488.1  acyl-CoA-binding protein isoform 4

    See identical proteins and their annotated locations for NP_001171488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, as compared to variant 5. The resulting isoform (4) has a longer and distinct N-terminus, compared to isoform 5.
    Source sequence(s)
    BC062996, FM213127
    Consensus CDS
    CCDS54391.1
    UniProtKB/Swiss-Prot
    P07108
    Related
    ENSP00000486361.1, ENST00000627305.2
    Conserved Domains (1) summary
    cd00435
    Location:74147
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  4. NM_001178041.2NP_001171512.1  acyl-CoA-binding protein isoform 5

    See identical proteins and their annotated locations for NP_001171512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) consists of five exons and encodes a 129aa protein (isoform 5).
    Source sequence(s)
    BM768076, BU599304, FM213128
    Consensus CDS
    CCDS54390.1
    UniProtKB/Swiss-Prot
    P07108
    Related
    ENSP00000486281.1, ENST00000627093.2
    Conserved Domains (1) summary
    cd00435
    Location:55128
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  5. NM_001178042.2NP_001171513.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001171513.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate exon in the 5' region, which results in an alternate translation start codon, as compared to variant 5. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 5. Variants 1, 7, 8, 9 and 10 encode the same isoform 1.
    Source sequence(s)
    BM768076, BU599304, FM213126
    Consensus CDS
    CCDS2126.1
    UniProtKB/Swiss-Prot
    P07108
    UniProtKB/TrEMBL
    A0A024RAF2
    Conserved Domains (1) summary
    cd00435
    Location:30103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  6. NM_001178043.2NP_001171514.1  acyl-CoA-binding protein isoform 6

    See identical proteins and their annotated locations for NP_001171514.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate splice site and lacks an in-frame exon in the 5' coding region, as compared to variant 5. The resulting isoform (6) has a shorter and alternate segment in the N-terminal region, compared to isoform 5.
    Source sequence(s)
    BM768076, BU599304, FM213122
    Consensus CDS
    CCDS74568.1
    UniProtKB/TrEMBL
    B8ZWD1
    Related
    ENSP00000442917.2, ENST00000535617.5
    Conserved Domains (1) summary
    cd00435
    Location:2396
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  7. NM_001282633.1NP_001269562.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001269562.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate splice site and an alternate exon in the 5' region, which results in an alternate translation start codon, compared to variant 5. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 5. Variants 1, 7, 8, 9, and 10 encode the same isoform 1.
    Source sequence(s)
    BM768076, BU599304, FM213123
    Consensus CDS
    CCDS2126.1
    UniProtKB/Swiss-Prot
    P07108
    UniProtKB/TrEMBL
    A0A024RAF2
    Related
    ENSP00000439012.1, ENST00000535757.5
    Conserved Domains (1) summary
    cd00435
    Location:30103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  8. NM_001282634.1NP_001269563.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001269563.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate exon in the 5' region, which results in an alternate translation start codon, compared to variant 5. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 5. Variants 1, 7, 8, 9, and 10 encode the same isoform 1.
    Source sequence(s)
    BM768076, BU599304, FM213125
    Consensus CDS
    CCDS2126.1
    UniProtKB/Swiss-Prot
    P07108
    UniProtKB/TrEMBL
    A0A024RAF2
    Related
    ENSP00000386486.1, ENST00000409094.5
    Conserved Domains (1) summary
    cd00435
    Location:30103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  9. NM_001282635.1NP_001269564.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001269564.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and 5' coding region, compared to variant 5. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 5. Variants 1, 7, 8, 9, and 10 encode the same isoform 1.
    Source sequence(s)
    BM768076, FM213131
    Consensus CDS
    CCDS2126.1
    UniProtKB/Swiss-Prot
    P07108
    UniProtKB/TrEMBL
    A0A024RAF2
    Related
    ENSP00000311117.4, ENST00000311521.8
    Conserved Domains (1) summary
    cd00435
    Location:30103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  10. NM_001282636.1NP_001269565.1  acyl-CoA-binding protein isoform 7

    See identical proteins and their annotated locations for NP_001269565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and lacks a portion of the 5' coding region, and initiates translation at a down stream start codon, compared to variant 5. The encoded isoform (7) has a shorter N-terminus, compared to isoform 5.
    Source sequence(s)
    BM768076, FM213129
    UniProtKB/TrEMBL
    B8ZWD8
    Conserved Domains (1) summary
    cl00221
    Location:162
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  11. NM_001352432.1NP_001339361.1  acyl-CoA-binding protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    BM768076, FM213130
    Conserved Domains (1) summary
    cl00221
    Location:162
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
  12. NM_020548.7NP_065438.1  acyl-CoA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_065438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as 1b) has an alternate splice site and an alternate exon in the 5' region, which results in an alternate translation start codon, as compared to variant 5. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 5. Variants 1, 7, 8, 9 and 10 encode the same isoform 1.
    Source sequence(s)
    BM768076, BU599304, FM213124
    Consensus CDS
    CCDS2126.1
    UniProtKB/Swiss-Prot
    P07108
    UniProtKB/TrEMBL
    A0A024RAF2
    Conserved Domains (1) summary
    cd00435
    Location:30103
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    119366924..119372551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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