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Cd55 CD55 molecule, decay accelerating factor for complement [ Mus musculus (house mouse) ]

Gene ID: 13136, updated on 23-Mar-2024

Summary

Official Symbol
Cd55provided by MGI
Official Full Name
CD55 molecule, decay accelerating factor for complementprovided by MGI
Primary source
MGI:MGI:104850
See related
Ensembl:ENSMUSG00000026399 AllianceGenome:MGI:104850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Daf; Daf1; Daf-GPI; GPI-DAF
Summary
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]
Expression
Broad expression in bladder adult (RPKM 9.5), testis adult (RPKM 5.4) and 20 other tissues See more
Orthologs
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Genomic context

See Cd55 in Genome Data Viewer
Location:
1 E4; 1 56.89 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130357526..130390513, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130429798..130465009, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02193 Neighboring gene predicted gene, 41951 Neighboring gene STARR-seq mESC enhancer starr_02194 Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene zona pellucida 3 receptor Neighboring gene predicted gene, 23623

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • AC111067.4

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement decay-accelerating factor, GPI-anchored
Names
CD55 antigen
Cromer blood group
GPI anchor addition signal
complement-glycosylphosphatidylinositol
decay accelerating factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404959.1NP_001391888.1  complement decay-accelerating factor, GPI-anchored isoform 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC111067
  2. NM_001404960.2NP_001391889.1  complement decay-accelerating factor, GPI-anchored isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC111067
  3. NM_001420093.1NP_001407022.1  complement decay-accelerating factor, GPI-anchored isoform 4 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC111067
  4. NM_010016.5NP_034146.2  complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_034146.2

    Status: REVIEWED

    Source sequence(s)
    AC111067
    Consensus CDS
    CCDS15256.1
    UniProtKB/Swiss-Prot
    P97732, Q3TU32, Q4FJS4, Q61397, Q61475, Q76N72, Q921P0, Q9R1C1
    Related
    ENSMUSP00000027650.7, ENSMUST00000027650.13
    Conserved Domains (2) summary
    cd00033
    Location:225285
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)

RNA

  1. NR_175895.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC111067
  2. NR_175896.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC111067

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130357526..130390513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246237.2XP_030102097.1  complement decay-accelerating factor, GPI-anchored isoform X2

    Conserved Domains (3) summary
    pfam00802
    Location:285361
    Glycoprotein_G; Pneumovirus attachment glycoprotein G
    cd00033
    Location:3695
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:98292
    PHA02927; secreted complement-binding protein; Provisional