Cd55 CD55 molecule, decay accelerating factor for complement [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd55provided by MGI
Official Full Name: CD55 molecule, decay accelerating factor for complementprovided by MGI
Primary source: MGI:MGI:104850
See related: Ensembl:ENSMUSG00000026399 AllianceGenome:MGI:104850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Daf; Daf1; Daf-GPI; GPI-DAF
Summary: This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]
Expression: Broad expression in bladder adult (RPKM 9.5), testis adult (RPKM 5.4) and 20 other tissues See more
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Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130357526..130392746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (130429798..130465009, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.
Title: Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.
Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.
Title: Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.
DAF is required for the properties of CD103(+) DCs and their naive CD4(+) cell partners that together program tolerance.
Title: CD55 Is Essential for CD103(+) Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.
CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.
Title: Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.
regulates self-renewal and cisplatin resistance in endometrioid tumors
Title: CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors.
Results show that definitive endoderm (DE) expressing Daf1 are slowly proliferating and adhesive cells suggesting that Daf1 is a marker of late stage DE.
Title: Late stage definitive endodermal differentiation can be defined by Daf1 expression.
these data show a key role for HIF-1alpha in regulating the expression of CD55 on airway epithelium.
Title: Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium.
CD55 is produced by the synovium and deposited on local collagen fiber meshwork, where it protects against immune complex-mediated arthritis.
Title: CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.
Fibrosis in Daf1-/- mice was accompanied by high expression of alpha-smooth muscle actin.
Title: Decay-accelerating factor 1 deficiency exacerbates leptospiral-induced murine chronic nephritis and renal fibrosis.
the downregulation of CD55 expression precedes, and has an important role regarding, the activation of C3 in the occurrence and development of DNP.
Title: A preliminary study on the role of the complement regulatory protein, cluster of differentiation 55, in mice with diabetic neuropathic pain.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI323748 (e-PCR)
- UniSTS:178457

NoName (e-PCR)
- UniSTS:225316

C87253 (e-PCR)
- UniSTS:207202

Daf1 (e-PCR), detects polymorphism
- UniSTS:142827

Homology

Homologs of the Cd55 gene: The Cd55 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of complement activation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of complement activation, classical pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement decay-accelerating factor, GPI-anchored

Names: CD55 antigen; Cromer blood group; GPI anchor addition signal; complement-glycosylphosphatidylinositol; decay accelerating factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404959.1 → NP_001391888.1 complement decay-accelerating factor, GPI-anchored isoform 2 preproprotein

Status: REVIEWED

Source sequence(s)

AC111067
NM_001404960.1 → NP_001391889.1 complement decay-accelerating factor, GPI-anchored isoform 3 preproprotein

Status: REVIEWED

Source sequence(s)

AC111067
NM_010016.4 → NP_034146.2 complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein

See identical proteins and their annotated locations for NP_034146.2

Status: REVIEWED

Source sequence(s)

AC111067

Consensus CDS

CCDS15256.1

UniProtKB/Swiss-Prot

Q61475, Q9R1C1

Related

ENSMUSP00000027650.7, ENSMUST00000027650.13

Conserved Domains (2) summary

cd00033
Location:225 → 285

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam00084
Location:98 → 158

Sushi; Sushi repeat (SCR repeat)

RNA

NR_175895.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC111067
NR_175896.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC111067

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

130357526..130392746 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246237.2 → XP_030102097.1 complement decay-accelerating factor, GPI-anchored isoform X2

Conserved Domains (3) summary

pfam00802
Location:285 → 361

Glycoprotein_G; Pneumovirus attachment glycoprotein G

cd00033
Location:36 → 95

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:98 → 292

PHA02927; secreted complement-binding protein; Provisional
XM_036158038.1 → XP_036013931.1 complement decay-accelerating factor, GPI-anchored isoform X4

Conserved Domains (2) summary

PHA02927
Location:4 → 177

PHA02927; secreted complement-binding protein; Provisional

NF033201
Location:155 → 260

Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
XM_006529115.5 → XP_006529178.1 complement decay-accelerating factor, GPI-anchored isoform X1

Conserved Domains (3) summary

pfam00802
Location:285 → 361

Glycoprotein_G; Pneumovirus attachment glycoprotein G

cd00033
Location:36 → 95

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:98 → 292

PHA02927; secreted complement-binding protein; Provisional
XM_006529117.5 → XP_006529180.1 complement decay-accelerating factor, GPI-anchored isoform X3

Conserved Domains (2) summary

pfam00802
Location:170 → 246

Glycoprotein_G; Pneumovirus attachment glycoprotein G

PHA02927
Location:4 → 177

PHA02927; secreted complement-binding protein; Provisional