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CD55 CD55 molecule (Cromer blood group) [ Homo sapiens (human) ]

Gene ID: 1604, updated on 12-Jan-2019

Summary

Official Symbol
CD55provided by HGNC
Official Full Name
CD55 molecule (Cromer blood group)provided by HGNC
Primary source
HGNC:HGNC:2665
See related
Ensembl:ENSG00000196352 MIM:125240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CR; TC; DAF; CROM; CHAPLE
Summary
This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
Expression
Broad expression in lung (RPKM 90.6), adrenal (RPKM 63.8) and 23 other tissues See more
Orthologs

Genomic context

See CD55 in Genome Data Viewer
Location:
1q32.2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (207321472..207360966)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207494817..207534311)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene C4BPA pseudogene 3 Neighboring gene C4BPA pseudogene 2 Neighboring gene uncharacterized LOC105372880 Neighboring gene complement C3d receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD55 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The complement regulatory proteins CD55 (DAF) and CD59 (HRF20) exist on HIV-1 virions, along with HIV-1 gp120 molecules, suggesting an interaction between these proteins and gp120 PubMed
env Inhibition of DAF or use of factor H depleted sera significantly increases C3 deposition on recombinant HIV-1 gp120 coated CD4 cells PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Gag co-localizes with the lipid raft marker CD55 or the tetraspanin CD81 in HeLa P4-R5 cells PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with the lipid raft marker CD55 or the tetraspanin CD81 in HeLa P4-R5 cells PubMed
gag HIV-1 Gag recruits and traps CD9 to Gag assembly sites at the plasma membrane, which is dependent upon Gag polymerization and the presence of cholesterol PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • Complement Activation, organism-specific biosystem (from WikiPathways)
    Complement Activation, organism-specific biosystemThe complement system is a biochemical cascade that helps, or complements, the ability of antibodies to clear pathogens from an organism. It is part of the immune system called the innate immune syst...
  • Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
    Complement and Coagulation Cascades, organism-specific biosystemBlood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the for...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement cascade, organism-specific biosystem (from REACTOME)
    Complement cascade, organism-specific biosystemIn the complement cascade, a panel of soluble molecules rapidly and effectively senses a danger or damage and triggers reactions to provide a response that discriminates among foreign intruders, cell...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Regulation of Complement cascade, organism-specific biosystem (from REACTOME)
    Regulation of Complement cascade, organism-specific biosystemTwo inherent features of complement activation make its regulation very important: 1. There is an inherent positive feedback loop because the product of C3 activation forms part of an enzyme that cau...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
complement decay-accelerating factor
Names
CD55 antigen
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Cromer blood group antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007465.1 RefSeqGene

    Range
    5001..44495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_127

mRNA and Protein(s)

  1. NM_000574.4NP_000565.1  complement decay-accelerating factor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_000565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as gDAF), which is membrane-associated.
    Source sequence(s)
    AW316643, BC001288, DC386415, M31516
    Consensus CDS
    CCDS31006.1
    UniProtKB/Swiss-Prot
    P08174
    Related
    ENSP00000356031.3, ENST00000367064.8
    Conserved Domains (2) summary
    smart00032
    Location:3694
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cl27761
    Location:98280
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  2. NM_001114752.2NP_001108224.1  complement decay-accelerating factor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001108224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2, also known as sDAF or soluble DAF) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AW316643, DC386415, M30142
    Consensus CDS
    CCDS44307.1
    UniProtKB/Swiss-Prot
    P08174
    Related
    ENSP00000316333.8, ENST00000314754.12
    Conserved Domains (4) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:3694
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
    pfam13900
    Location:365400
    GVQW; Putative domain of unknown function
  3. NM_001300902.1NP_001287831.1  complement decay-accelerating factor isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AF052110, DC386415
    Consensus CDS
    CCDS73022.1
    UniProtKB/TrEMBL
    B1AP13
    Related
    ENSP00000356030.2, ENST00000367063.6
    Conserved Domains (4) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:3694
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
    pfam13900
    Location:365412
    GVQW; Putative domain of unknown function
  4. NM_001300903.1NP_001287832.1  complement decay-accelerating factor isoform 6 precursor

    See identical proteins and their annotated locations for NP_001287832.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (6, also known as vDAF1) has a distinct C-terminus and is longer than isoform 1. This isoform is likely soluble (PMID:16503113).
    Source sequence(s)
    AB240566, AL391597, AW316643, DC386415, M30142
    Consensus CDS
    CCDS86046.1
    UniProtKB/Swiss-Prot
    P08174
    Related
    ENSP00000496251.1, ENST00000645323.1
    Conserved Domains (4) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:3694
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)
    pfam13900
    Location:378403
    GVQW; Putative domain of unknown function
  5. NM_001300904.1NP_001287833.1  complement decay-accelerating factor isoform 7 precursor

    See identical proteins and their annotated locations for NP_001287833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (7, also known as vDAF3) has a distinct C-terminus and is longer than isoform 1. This isoform is likely soluble (PMID:16503113).
    Source sequence(s)
    AB240568, AW316643, DC386415, M30142
    Consensus CDS
    CCDS86047.1
    UniProtKB/Swiss-Prot
    P08174
    Related
    ENSP00000495518.1, ENST00000644836.1
    Conserved Domains (3) summary
    cd00033
    Location:225284
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:3694
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    pfam00084
    Location:98158
    Sushi; Sushi repeat (SCR repeat)

RNA

  1. NR_125349.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB240567, AW316643, DC386415, M30142

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    207321472..207360966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000467.2XP_016855956.1  complement decay-accelerating factor isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001114543.1: Suppressed sequence

    Description
    NM_001114543.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_001114544.1: Suppressed sequence

    Description
    NM_001114544.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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