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UBR3 ubiquitin protein ligase E3 component n-recognin 3 [ Homo sapiens (human) ]

Gene ID: 130507, updated on 23-Nov-2021

Summary

Official Symbol
UBR3provided by HGNC
Official Full Name
ubiquitin protein ligase E3 component n-recognin 3provided by HGNC
Primary source
HGNC:HGNC:30467
See related
Ensembl:ENSG00000144357 MIM:613831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF650
Expression
Ubiquitous expression in brain (RPKM 13.7), thyroid (RPKM 11.5) and 25 other tissues See more
Orthologs
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Genomic context

See UBR3 in Genome Data Viewer
Location:
2q31.1
Exon count:
39
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (169827454..170084131)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170683964..170940641)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 3K Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene Sharpr-MPRA regulatory region 15130 Neighboring gene VISTA enhancer hs1867 Neighboring gene RNA, U6 small nuclear 1006, pseudogene Neighboring gene NSA2 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 12880 Neighboring gene myosin IIIB

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37422, KIAA2024, MGC126489, DKFZp434P117, DKFZp686N10185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of smell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in suckling behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase UBR3
Names
N-recognin-3
RING-type E3 ubiquitin transferase UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
ubiquitin-protein ligase E3-alpha-3
ubiquitin-protein ligase E3-alpha-III
zinc finger protein 650
NP_742067.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172070.4NP_742067.3  E3 ubiquitin-protein ligase UBR3

    See identical proteins and their annotated locations for NP_742067.3

    Status: VALIDATED

    Source sequence(s)
    AC009967, AC092641, AI142128, BC044060, BC113010, BF446017, BU158552, BX281113, BX494687, DA108743, DA234864, DA301129, DA352029, DN831941, DR731153
    Consensus CDS
    CCDS2238.2
    UniProtKB/Swiss-Prot
    Q6ZT12
    Related
    ENSP00000272793.5, ENST00000272793.11
    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    169827454..170084131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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