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UBR3 ubiquitin protein ligase E3 component n-recognin 3 [ Homo sapiens (human) ]

Gene ID: 130507, updated on 5-Aug-2018

Summary

Official Symbol
UBR3provided by HGNC
Official Full Name
ubiquitin protein ligase E3 component n-recognin 3provided by HGNC
Primary source
HGNC:HGNC:30467
See related
Ensembl:ENSG00000144357 MIM:613831; Vega:OTTHUMG00000132229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF650
Expression
Ubiquitous expression in brain (RPKM 13.7), thyroid (RPKM 11.5) and 25 other tissues See more
Orthologs

Genomic context

See UBR3 in Genome Data Viewer
Location:
2q31.1
Exon count:
45
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (169827462..170084131)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170684010..170940641)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 3K Neighboring gene methyltransferase like 5 Neighboring gene Sjogren syndrome antigen B Neighboring gene VISTA enhancer hs1867 Neighboring gene NSA2 ribosome biogenesis homolog (S. cerevisiae) pseudogene Neighboring gene RNA, U6 small nuclear 1006, pseudogene Neighboring gene uncharacterized LOC105373735 Neighboring gene myosin IIIB

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37422, KIAA2024, MGC126489, DKFZp434P117, DKFZp686N10185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
embryo development ending in birth or egg hatching ISS
Inferred from Sequence or Structural Similarity
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
olfactory behavior IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
sensory perception of smell ISS
Inferred from Sequence or Structural Similarity
more info
 
suckling behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase UBR3
Names
N-recognin-3
RING-type E3 ubiquitin transferase UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
ubiquitin-protein ligase E3-alpha-3
ubiquitin-protein ligase E3-alpha-III
zinc finger protein 650
NP_742067.3
XP_005246356.1
XP_005246357.1
XP_006712331.1
XP_006712332.1
XP_006712333.2
XP_006712334.1
XP_011508906.1
XP_016858845.1
XP_016858846.1
XP_016858847.1
XP_016858848.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172070.3NP_742067.3  E3 ubiquitin-protein ligase UBR3

    See identical proteins and their annotated locations for NP_742067.3

    Status: VALIDATED

    Source sequence(s)
    AC009967, AI142128, BC044060, BC113010, BF446017, BU158552, BU686724, BX281113, BX494687, DA108743, DA234864, DA301129, DA352029, DN831941, DR731153
    Consensus CDS
    CCDS2238.2
    UniProtKB/Swiss-Prot
    Q6ZT12
    Related
    ENSP00000396068.1, ENST00000418381.5
    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    169827462..170084131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712268.4XP_006712331.1  E3 ubiquitin-protein ligase UBR3 isoform X2

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  2. XM_006712271.4XP_006712334.1  E3 ubiquitin-protein ligase UBR3 isoform X11

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  3. XM_005246299.4XP_005246356.1  E3 ubiquitin-protein ligase UBR3 isoform X1

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  4. XM_006712270.3XP_006712333.2  E3 ubiquitin-protein ligase UBR3 isoform X5

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  5. XM_005246300.4XP_005246357.1  E3 ubiquitin-protein ligase UBR3 isoform X3

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  6. XM_006712269.3XP_006712332.1  E3 ubiquitin-protein ligase UBR3 isoform X4

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  7. XM_017003356.2XP_016858845.1  E3 ubiquitin-protein ligase UBR3 isoform X6

  8. XM_011510604.2XP_011508906.1  E3 ubiquitin-protein ligase UBR3 isoform X7

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  9. XM_017003358.1XP_016858847.1  E3 ubiquitin-protein ligase UBR3 isoform X9

  10. XM_017003357.1XP_016858846.1  E3 ubiquitin-protein ligase UBR3 isoform X8

    Conserved Domains (1) summary
    pfam02207
    Location:120187
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  11. XM_017003359.1XP_016858848.1  E3 ubiquitin-protein ligase UBR3 isoform X10

RNA

  1. XR_922841.2 RNA Sequence

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