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Cux2 cut-like homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 13048, updated on 19-Jun-2024

Summary

Official Symbol
Cux2provided by MGI
Official Full Name
cut-like homeobox 2provided by MGI
Primary source
MGI:MGI:107321
See related
Ensembl:ENSMUSG00000042589 AllianceGenome:MGI:107321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cutl2; Cux-2; 1700051K22Rik
Summary
This gene is a member of the Cut family of transcription factors that have multiple DNA binding domains and regulate cell proliferation and differentiation. This gene is primarily expressed in nervous tissues where it controls the proliferation of neuronal precursors, and may play a role in organogenesis earlier during embryonic development. Mice lacking the encoded protein exhibit smaller spinal cords with deficits in neural progenitor development as well as in neuroblast and interneuron differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Biased expression in cortex adult (RPKM 10.2), frontal lobe adult (RPKM 7.6) and 14 other tissues See more
Orthologs
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Genomic context

See Cux2 in Genome Data Viewer
Location:
5 F; 5 62.02 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121996025..122188522, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121857962..122050415, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:122298757-122299058 Neighboring gene predicted gene, 32422 Neighboring gene PH domain containing endocytic trafficking adaptor 1 Neighboring gene predicted gene, 52785 Neighboring gene uncharacterized LOC118568726 Neighboring gene predicted gene, 52786 Neighboring gene VISTA enhancer mm77 Neighboring gene myosin, light polypeptide 2, regulatory, cardiac, slow Neighboring gene coiled-coil domain containing 63

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox protein cut-like 2
Names
homeobox protein Cux-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312908.2NP_001299837.1  homeobox protein cut-like 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC113302, AC140353
    Consensus CDS
    CCDS39251.1
    UniProtKB/Swiss-Prot
    P70298, Q6P1E6
    Related
    ENSMUSP00000107381.3, ENSMUST00000111752.10
    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11161170
    Homeobox; Homeobox domain
    pfam02376
    Location:9881064
    CUT; CUT domain
  2. NM_001415780.2NP_001402709.1  homeobox protein cut-like 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC113302, AC140353
  3. NM_001428516.1NP_001415445.1  homeobox protein cut-like 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC113302, AC140353
    UniProtKB/Swiss-Prot
    P70298, Q6P1E6
  4. NM_001428517.1NP_001415446.1  homeobox protein cut-like 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC113302, AC124189
    UniProtKB/Swiss-Prot
    P70298, Q6P1E6
  5. NM_001428518.1NP_001415447.1  homeobox protein cut-like 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC113302, AC124189
  6. NM_007804.3NP_031830.2  homeobox protein cut-like 2 isoform 1

    See identical proteins and their annotated locations for NP_031830.2

    Status: REVIEWED

    Source sequence(s)
    AC113302, AC140353
    Consensus CDS
    CCDS39251.1
    UniProtKB/Swiss-Prot
    P70298, Q6P1E6
    Related
    ENSMUSP00000083497.6, ENSMUST00000086317.12
    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11161170
    Homeobox; Homeobox domain
    pfam02376
    Location:9881064
    CUT; CUT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121996025..122188522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248166.4XP_011246468.1  homeobox protein cut-like 2 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:199393
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:12051259
    Homeobox; Homeobox domain
    pfam02376
    Location:10771150
    CUT; CUT domain
  2. XM_030254117.2XP_030109977.1  homeobox protein cut-like 2 isoform X3

    Conserved Domains (3) summary
    COG1196
    Location:274505
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:12651319
    Homeobox; Homeobox domain
    pfam02376
    Location:11371210
    CUT; CUT domain
  3. XM_030254116.2XP_030109976.1  homeobox protein cut-like 2 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:279473
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:12741328
    Homeobox; Homeobox domain
    pfam02376
    Location:11461219
    CUT; CUT domain
  4. XM_011248171.4XP_011246473.2  homeobox protein cut-like 2 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:279473
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:12851339
    Homeobox; Homeobox domain
    pfam02376
    Location:11571230
    CUT; CUT domain
  5. XM_011248173.3XP_011246475.1  homeobox protein cut-like 2 isoform X6

    See identical proteins and their annotated locations for XP_011246475.1

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11271181
    Homeobox; Homeobox domain
    pfam02376
    Location:9991072
    CUT; CUT domain
  6. XM_030254118.2XP_030109978.1  homeobox protein cut-like 2 isoform X7

    UniProtKB/Swiss-Prot
    P70298, Q6P1E6
    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11161170
    Homeobox; Homeobox domain
    pfam02376
    Location:9881064
    CUT; CUT domain
  7. XM_011248167.3XP_011246469.1  homeobox protein cut-like 2 isoform X6

    See identical proteins and their annotated locations for XP_011246469.1

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11271181
    Homeobox; Homeobox domain
    pfam02376
    Location:9991072
    CUT; CUT domain
  8. XM_030254119.2XP_030109979.1  homeobox protein cut-like 2 isoform X7

    UniProtKB/Swiss-Prot
    P70298, Q6P1E6
    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11161170
    Homeobox; Homeobox domain
    pfam02376
    Location:9881064
    CUT; CUT domain
  9. XM_011248168.4XP_011246470.1  homeobox protein cut-like 2 isoform X6

    See identical proteins and their annotated locations for XP_011246470.1

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11271181
    Homeobox; Homeobox domain
    pfam02376
    Location:9991072
    CUT; CUT domain
  10. XM_011248169.4XP_011246471.1  homeobox protein cut-like 2 isoform X6

    See identical proteins and their annotated locations for XP_011246471.1

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11271181
    Homeobox; Homeobox domain
    pfam02376
    Location:9991072
    CUT; CUT domain
  11. XM_011248170.4XP_011246472.1  homeobox protein cut-like 2 isoform X6

    See identical proteins and their annotated locations for XP_011246472.1

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11271181
    Homeobox; Homeobox domain
    pfam02376
    Location:9991072
    CUT; CUT domain
  12. XM_011248172.4XP_011246474.1  homeobox protein cut-like 2 isoform X6

    See identical proteins and their annotated locations for XP_011246474.1

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11271181
    Homeobox; Homeobox domain
    pfam02376
    Location:9991072
    CUT; CUT domain
  13. XM_036164774.1XP_036020667.1  homeobox protein cut-like 2 isoform X7

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11161170
    Homeobox; Homeobox domain
    pfam02376
    Location:9881064
    CUT; CUT domain
  14. XM_011248176.4XP_011246478.1  homeobox protein cut-like 2 isoform X6

    See identical proteins and their annotated locations for XP_011246478.1

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:11271181
    Homeobox; Homeobox domain
    pfam02376
    Location:9991072
    CUT; CUT domain
  15. XM_036164775.1XP_036020668.1  homeobox protein cut-like 2 isoform X8

    Conserved Domains (3) summary
    COG1196
    Location:121315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:10961150
    Homeobox; Homeobox domain
    pfam02376
    Location:9681044
    CUT; CUT domain
  16. XM_017320655.3XP_017176144.1  homeobox protein cut-like 2 isoform X9

    Conserved Domains (3) summary
    COG1196
    Location:4132
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:9481002
    Homeobox; Homeobox domain
    pfam02376
    Location:820893
    CUT; CUT domain
  17. XM_030254120.2XP_030109980.1  homeobox protein cut-like 2 isoform X9

    Conserved Domains (3) summary
    COG1196
    Location:4132
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam00046
    Location:9481002
    Homeobox; Homeobox domain
    pfam02376
    Location:820893
    CUT; CUT domain