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CUX2 cut like homeobox 2 [ Homo sapiens (human) ]

Gene ID: 23316, updated on 22-Aug-2020

Summary

Official Symbol
CUX2provided by HGNC
Official Full Name
cut like homeobox 2provided by HGNC
Primary source
HGNC:HGNC:19347
See related
Ensembl:ENSG00000111249 MIM:610648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDP2; CUTL2; EIEE67
Summary
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
Expression
Biased expression in prostate (RPKM 4.9), liver (RPKM 4.6) and 3 other tissues See more
Orthologs

Genomic context

See CUX2 in Genome Data Viewer
Location:
12q24.11-q24.12
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (111034165..111350556)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (111471828..111788358)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369980 Neighboring gene uncharacterized LOC105369981 Neighboring gene VISTA enhancer hs611 Neighboring gene uncharacterized LOC105369983 Neighboring gene microRNA 6760 Neighboring gene RNA, 5S ribosomal pseudogene 373 Neighboring gene PH domain containing endocytic trafficking adaptor 1 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.
GeneReviews: Not available
A genome-wide association study of a coronary artery disease risk variant.
GeneReviews: Not available
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 67
MedGen: C4748341 OMIM: 618141 GeneReviews: Not available
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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Golgi vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
 
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
short-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein cut-like 2
Names
homeobox protein cux-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023039.2 RefSeqGene

    Range
    5142..321531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370598.1NP_001357527.1  homeobox protein cut-like 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002352, AC002978, AC002979, AC005805
    Conserved Domains (3) summary
    TIGR02168
    Location:111308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02376
    Location:9811057
    CUT; CUT domain
    pfam00046
    Location:11091163
    Homeobox; Homeobox domain
  2. NM_015267.4NP_056082.2  homeobox protein cut-like 2 isoform 1

    See identical proteins and their annotated locations for NP_056082.2

    Status: REVIEWED

    Source sequence(s)
    AC005805, BC151245
    Consensus CDS
    CCDS41837.1
    UniProtKB/Swiss-Prot
    O14529
    Related
    ENSP00000261726.6, ENST00000261726.11
    Conserved Domains (3) summary
    PHA03418
    Location:12181378
    PHA03418; hypothetical E4 protein; Provisional
    pfam00046
    Location:11711224
    Homeobox; Homeobox domain
    pfam02376
    Location:10431119
    CUT; CUT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    111034165..111350556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019081.1XP_016874570.1  homeobox protein cut-like 2 isoform X3

    Conserved Domains (3) summary
    TIGR02168
    Location:111308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02376
    Location:9811057
    CUT; CUT domain
    pfam00046
    Location:11091163
    Homeobox; Homeobox domain
  2. XM_011538069.2XP_011536371.1  homeobox protein cut-like 2 isoform X3

    See identical proteins and their annotated locations for XP_011536371.1

    Conserved Domains (3) summary
    TIGR02168
    Location:111308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02376
    Location:9811057
    CUT; CUT domain
    pfam00046
    Location:11091163
    Homeobox; Homeobox domain
  3. XM_017019080.1XP_016874569.1  homeobox protein cut-like 2 isoform X3

    Conserved Domains (3) summary
    TIGR02168
    Location:111308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02376
    Location:9811057
    CUT; CUT domain
    pfam00046
    Location:11091163
    Homeobox; Homeobox domain
  4. XM_011538070.2XP_011536372.1  homeobox protein cut-like 2 isoform X3

    See identical proteins and their annotated locations for XP_011536372.1

    Conserved Domains (3) summary
    TIGR02168
    Location:111308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02376
    Location:9811057
    CUT; CUT domain
    pfam00046
    Location:11091163
    Homeobox; Homeobox domain
  5. XM_011538063.3XP_011536365.1  homeobox protein cut-like 2 isoform X2

    Conserved Domains (3) summary
    PHA03418
    Location:12501389
    PHA03418; hypothetical E4 protein; Provisional
    pfam00046
    Location:11821235
    Homeobox; Homeobox domain
    pfam02376
    Location:10541130
    CUT; CUT domain
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