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Celf1 CUGBP, Elav-like family member 1 [ Mus musculus (house mouse) ]

Gene ID: 13046, updated on 2-Nov-2024

Summary

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Official Symbol
Celf1provided by MGI
Official Full Name
CUGBP, Elav-like family member 1provided by MGI
Primary source
MGI:MGI:1342295
See related
Ensembl:ENSMUSG00000005506 AllianceGenome:MGI:1342295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CUGBP; NAB50; CUG-BP; Cugbp1; HNAB50; Brunol2; CUG-BP1; D2Wsu101e; 1600010O03Rik
Summary
Enables lncRNA binding activity; mRNA binding activity; and translation initiation factor binding activity. Acts upstream of or within several processes, including mRNA splice site recognition; regulation of alternative mRNA splicing, via spliceosome; and spermatid development. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including branchial arch; central nervous system; early embryo; musculature; and testis. Orthologous to human CELF1 (CUGBP Elav-like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 28.2), whole brain E14.5 (RPKM 28.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Celf1 in Genome Data Viewer
Location:
2 E1; 2 50.44 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90770604..90849842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90940259..91019497)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 4 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 Neighboring gene STARR-seq mESC enhancer starr_05099 Neighboring gene STARR-seq mESC enhancer starr_05101 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90854051-90854352 Neighboring gene STARR-positive B cell enhancer ABC_E5944 Neighboring gene receptor-associated protein of the synapse Neighboring gene STARR-positive B cell enhancer ABC_E7840 Neighboring gene predicted gene 13778 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evaluating the effects of CELF1 deficiency in a mouse model of RNA toxicity. Kim YK, et al. Hum Mol Genet, 2014 Jan 15. PMID 24001600, Free PMC Article
  2. Inactivation of the Celf1 gene that encodes an RNA-binding protein delays the first wave of spermatogenesis in mice. Cibois M, et al. PLoS One, 2012. PMID 23056285, Free PMC Article
  3. The role of CUGBP1 in age-dependent changes of liver functions. Jones K, et al. Ageing Res Rev, 2012 Sep. PMID 22446383, Free PMC Article
  4. CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart. Belanger K, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30158053, Free PMC Article
  5. Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1. Wei C, et al. FASEB J, 2018 Apr. PMID 29203592, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.
    Title: High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.
  2. Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury.
    Title: Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury.
  3. Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting.
    Title: Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting.
  4. CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure.
    Title: CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure.
  5. The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
    Title: The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
  6. RNA-seq analysis of mouse neocortical polysomes demonstrated that the translation of distinct mRNA isoforms of the RNA binding protein (RBP), Elavl4, in radial glia progenitors and early neurons depends on its alternative 5' UTRs. 5' UTR-driven Elavl4 isoform-specific translation depends on upstream control by another RBP, Celf1. Celf1 regulation of Elavl4 translation dictates development of glutamatergic neurons.
    Title: Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development.
  7. miR-206 helped rescue myogenic deficiency by inhibiting CUGBP1 accumulation in cell models of myotonic dystrophy. These data suggest that increased miR-206 levels in myoblasts may lead to better skeletal muscle differentiation.
    Title: Mir-206 partially rescues myogenesis deficiency by inhibiting CUGBP1 accumulation in the cell models of myotonic dystrophy.
  8. These results indicate that CELF1 target RNAs are aberrantly spliced in the Type 1 diabetic heart leading to abnormal gene expression.
    Title: CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart.
  9. this study shows that the absence of Celf1 causes neonatal cardiac dysfunction and transcriptome changes
    Title: Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1.
  10. Results found that the blood level of CUGBP1 in mice was decreased during the progression of acute myocardial infarction (AMI) and demonstrate that CUGBP1 is functionally important in AMI. This finding reveals the roles of CUGBP1 in the heart not only during development but also in cardiac disease.
    Title: Reconstitution of HuR-Inhibited CUGBP1 Expression Protects Cardiomyocytes from Acute Myocardial Infarction-Induced Injury.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BRE binding ISO
Inferred from Sequence Orthology
more info
  
enables BRE binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA splice site recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splice site recognition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in perinucleolar compartment ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CUGBP Elav-like family member 1
Names
50 kDa nuclear polyadenylated RNA-binding protein
CELF-1
CUG triplet repeat RNA-binding protein 1
CUG-BP- and ETR-3-like factor 1
EDEN-BP homolog
RNA-binding protein BRUNOL-2
brain protein F41
bruno-like protein 2
deadenylation factor CUG-BP
deadenylation factor EDEN-BP
embryo deadenylation element-binding protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244891.2 → NP_001231820.1  CUGBP Elav-like family member 1 isoform 2

    See identical proteins and their annotated locations for NP_001231820.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate exon in the 5' region, which results in a downstream AUG start codon, and has an additional segment in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL672241
    Consensus CDS
    CCDS16421.1
    UniProtKB/Swiss-Prot
    A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37
    Related
    ENSMUSP00000136109.2, ENSMUST00000177642.8
    Conserved Domains (3) summary
    cd12638
    Location:394 → 485
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:15 → 98
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107 → 187
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  2. NM_001244903.2 → NP_001231832.1  CUGBP Elav-like family member 1 isoform 2

    See identical proteins and their annotated locations for NP_001231832.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in a downstream AUG start codon, and has an additional segment in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL672241
    Consensus CDS
    CCDS16421.1
    UniProtKB/Swiss-Prot
    A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37
    Related
    ENSMUSP00000070438.8, ENSMUST00000068747.14
    Conserved Domains (3) summary
    cd12638
    Location:394 → 485
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:15 → 98
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107 → 187
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  3. NM_001406164.1 → NP_001393093.1  CUGBP Elav-like family member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672241
    Related
    ENSMUSP00000107082.3, ENSMUST00000111455.9

  4. NM_001406165.1 → NP_001393094.1  CUGBP Elav-like family member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672241

  5. NM_001406166.1 → NP_001393095.1  CUGBP Elav-like family member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672241
    UniProtKB/Swiss-Prot
    A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37

  6. NM_001406167.1 → NP_001393096.1  CUGBP Elav-like family member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672241
    UniProtKB/Swiss-Prot
    A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37
    Related
    ENSMUSP00000107076.2, ENSMUST00000111449.8

  7. NM_001406168.1 → NP_001393097.1  CUGBP Elav-like family member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672241

  8. NM_001406169.1 → NP_001393098.1  CUGBP Elav-like family member 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672241

  9. NM_001406170.1 → NP_001393099.1  CUGBP Elav-like family member 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672241

  10. NM_001406171.1 → NP_001393100.1  CUGBP Elav-like family member 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672241

  11. NM_001406172.1 → NP_001393101.1  CUGBP Elav-like family member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672241
    UniProtKB/TrEMBL
    A0A0R4J0T5

  12. NM_001406173.1 → NP_001393102.1  CUGBP Elav-like family member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672241
    UniProtKB/TrEMBL
    A0A0R4J0T5

  13. NM_001406174.1 → NP_001393103.1  CUGBP Elav-like family member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672241
    UniProtKB/TrEMBL
    A0A0R4J0T5
    Related
    ENSMUSP00000064323.7, ENSMUST00000068726.13

  14. NM_001406175.1 → NP_001393104.1  CUGBP Elav-like family member 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672241
    UniProtKB/TrEMBL
    A0A0R4J0T5

  15. NM_001406176.1 → NP_001393105.1  CUGBP Elav-like family member 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL672241

  16. NM_001406177.1 → NP_001393106.1  CUGBP Elav-like family member 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL672241

  17. NM_001406178.1 → NP_001393107.1  CUGBP Elav-like family member 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL672241

  18. NM_001406179.1 → NP_001393108.1  CUGBP Elav-like family member 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL672241

  19. NM_001406180.1 → NP_001393109.1  CUGBP Elav-like family member 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL672241

  20. NM_001406181.1 → NP_001393110.1  CUGBP Elav-like family member 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL672241

  21. NM_001406182.1 → NP_001393111.1  CUGBP Elav-like family member 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL672241

  22. NM_001406183.1 → NP_001393112.1  CUGBP Elav-like family member 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL672241

  23. NM_001406184.1 → NP_001393113.1  CUGBP Elav-like family member 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL672241

  24. NM_017368.4 → NP_059064.2  CUGBP Elav-like family member 1 isoform 1

    See identical proteins and their annotated locations for NP_059064.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL672241
    Consensus CDS
    CCDS16420.1
    UniProtKB/Swiss-Prot
    P28659
    Related
    ENSMUSP00000005643.8, ENSMUST00000005643.14
    Conserved Domains (3) summary
    cd12638
    Location:421 → 512
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:42 → 125
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:134 → 214
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  25. NM_198683.3 → NP_941955.1  CUGBP Elav-like family member 1 isoform 2

    See identical proteins and their annotated locations for NP_941955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL672241
    Consensus CDS
    CCDS16421.1
    UniProtKB/Swiss-Prot
    A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37
    Related
    ENSMUSP00000107078.4, ENSMUST00000111451.10
    Conserved Domains (3) summary
    cd12638
    Location:394 → 485
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:15 → 98
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107 → 187
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    90770604..90849842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158049.1 → XP_036013942.1  CUGBP Elav-like family member 1 isoform X13

    Conserved Domains (3) summary
    cd12638
    Location:334 → 423
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:15 → 98
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107 → 187
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  2. XM_030247110.1 → XP_030102970.1  CUGBP Elav-like family member 1 isoform X7

    Related
    ENSMUSP00000107075.2, ENSMUST00000111448.2
    Conserved Domains (3) summary
    cd12631
    Location:15 → 98
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107 → 187
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:391 → 482
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  3. XM_030247123.1 → XP_030102983.1  CUGBP Elav-like family member 1 isoform X1

    Conserved Domains (3) summary
    cd12638
    Location:422 → 513
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:42 → 125
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:134 → 214
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  4. XM_030247114.1 → XP_030102974.1  CUGBP Elav-like family member 1 isoform X9

    Conserved Domains (3) summary
    cd12638
    Location:362 → 451
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:42 → 125
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:134 → 214
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  5. XM_036158039.1 → XP_036013932.1  CUGBP Elav-like family member 1 isoform X9

    Conserved Domains (3) summary
    cd12638
    Location:362 → 451
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:42 → 125
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:134 → 214
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  6. XM_030247118.1 → XP_030102978.1  CUGBP Elav-like family member 1 isoform X10

    Conserved Domains (3) summary
    cd12631
    Location:42 → 125
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:134 → 214
    RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12638
    Location:361 → 450
    RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  7. XM_030247086.1 → XP_030102946.1  CUGBP Elav-like family member 1 isoform X3

    Conserved Domains (3) summary
    cd12638
    Location:418 → 509
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:42 → 125
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:134 → 214
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  8. XM_017315295.1 → XP_017170784.1  CUGBP Elav-like family member 1 isoform X1

    Conserved Domains (3) summary
    cd12638
    Location:422 → 513
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:42 → 125
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:134 → 214
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  9. XM_036158048.1 → XP_036013941.1  CUGBP Elav-like family member 1 isoform X12

    Conserved Domains (3) summary
    cd12638
    Location:335 → 424
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:15 → 98
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107 → 187
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  10. XM_036158029.1 → XP_036013922.1  CUGBP Elav-like family member 1 isoform X5

    UniProtKB/TrEMBL
    A0A0R4J0T5
    Conserved Domains (3) summary
    cd12638
    Location:395 → 486
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:15 → 98
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:107 → 187
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198016.1: Suppressed sequence

    Description
    NM_198016.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28659.2 GenPept UniProtKB/Swiss-Prot:P28659

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