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Cttn cortactin [ Mus musculus (house mouse) ]

Gene ID: 13043, updated on 31-Oct-2021

Summary

Official Symbol
Cttnprovided by MGI
Official Full Name
cortactinprovided by MGI
Primary source
MGI:MGI:99695
See related
Ensembl:ENSMUSG00000031078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ems1; 1110020L01Rik
Expression
Ubiquitous expression in bladder adult (RPKM 56.4), colon adult (RPKM 53.9) and 28 other tissues See more
Orthologs
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Genomic context

See Cttn in Genome Data Viewer
Location:
7; 7 F5
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143989461..144024743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144435724..144471560, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (151621629..151656646, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene predicted gene, 34621 Neighboring gene predicted gene, 34561 Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Neighboring gene predicted gene, 35626 Neighboring gene Fas (TNFRSF6)-associated via death domain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables profilin binding ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lamellipodium organization ISO
Inferred from Sequence Orthology
more info
 
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell projection assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within substrate-dependent cell migration, cell extension IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
src substrate cortactin
Names
mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252572.1NP_001239501.1  src substrate cortactin isoform 2

    See identical proteins and their annotated locations for NP_001239501.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK084249, AK168871, AK168945, BY137811, BY265697, BY760295
    Consensus CDS
    CCDS57599.1
    UniProtKB/TrEMBL
    Q8BNA5, Q921L6
    Related
    ENSMUSP00000033407.7, ENSMUST00000033407.13
    Conserved Domains (3) summary
    cd11959
    Location:455507
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam02218
    Location:231266
    HS1_rep; Repeat in HS1/Cortactin
    cl05005
    Location:299362
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. NM_001357116.1NP_001344045.1  src substrate cortactin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC140268
    Conserved Domains (4) summary
    cd11959
    Location:418470
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam02218
    Location:157192
    HS1_rep; Repeat in HS1/Cortactin
    pfam15927
    Location:285326
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
    cl00489
    Location:272368
    60KD_IMP; 60Kd inner membrane protein
  3. NM_007803.5NP_031829.2  src substrate cortactin isoform 1

    See identical proteins and their annotated locations for NP_031829.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK168699, BY137811, BY265697, BY760295
    Consensus CDS
    CCDS22049.1
    UniProtKB/Swiss-Prot
    Q60598
    Related
    ENSMUSP00000099368.4, ENSMUST00000103079.4
    Conserved Domains (3) summary
    cd11959
    Location:492544
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam02218
    Location:157192
    HS1_rep; Repeat in HS1/Cortactin
    cl05005
    Location:336399
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143989461..144024743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001785469.3 RNA Sequence

  2. XR_003946381.2 RNA Sequence

  3. XR_003946382.2 RNA Sequence

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