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CTTN cortactin [ Homo sapiens (human) ]

Gene ID: 2017, updated on 17-May-2020

Summary

Official Symbol
CTTNprovided by HGNC
Official Full Name
cortactinprovided by HGNC
Primary source
HGNC:HGNC:3338
See related
Ensembl:ENSG00000085733 MIM:164765
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EMS1
Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in gall bladder (RPKM 41.5), adrenal (RPKM 38.4) and 25 other tissues See more
Orthologs

Genomic context

See CTTN in Genome Data Viewer
Location:
11q13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (70398506..70436584)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70244612..70282690)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369373 Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene uncharacterized LOC107984347 Neighboring gene SH3 and multiple ankyrin repeat domains 2 Neighboring gene Sharpr-MPRA regulatory region 3810 Neighboring gene SHANK2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated cortactin (CTTN) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
profilin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
lamellipodium organization ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of autophagy of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
substrate-dependent cell migration, cell extension IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
clathrin-coated pit ISS
Inferred from Sequence or Structural Similarity
more info
 
cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
colocalizes_with growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle midzone IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
podosome IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
src substrate cortactin
Names
1110020L01Rik
amplaxin
ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
epididymis secretory sperm binding protein
oncogene EMS1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029881.1 RefSeqGene

    Range
    5024..43070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184740.2NP_001171669.1  src substrate cortactin isoform c

    See identical proteins and their annotated locations for NP_001171669.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses different splice sites in the 3' coding region, which changes reading frame and the termination stop codon, compared to variant 1. The resulting protein (isoform c) has a longer and distinct C-terminus when it is compared to isoform a.
    Source sequence(s)
    AA325227, BC033889, DA716772
    Consensus CDS
    CCDS53676.1
    UniProtKB/Swiss-Prot
    Q14247
    Related
    ENSP00000365745.3, ENST00000376561.7
    Conserved Domains (3) summary
    pfam02218
    Location:231266
    HS1_rep; Repeat in HS1/Cortactin
    cl05005
    Location:288363
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17036
    Location:459501
    SH3; Src Homology 3 domain superfamily
  2. NM_005231.4NP_005222.2  src substrate cortactin isoform a

    See identical proteins and their annotated locations for NP_005222.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript.
    Source sequence(s)
    AK222613, AK291097, BC008799, DA716772
    Consensus CDS
    CCDS41680.1
    UniProtKB/Swiss-Prot
    Q14247
    UniProtKB/TrEMBL
    Q53HG7
    Related
    ENSP00000301843.8, ENST00000301843.13
    Conserved Domains (3) summary
    cd11959
    Location:496548
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam02218
    Location:231266
    HS1_rep; Repeat in HS1/Cortactin
    cl05005
    Location:325400
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  3. NM_138565.2NP_612632.1  src substrate cortactin isoform b

    See identical proteins and their annotated locations for NP_612632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment of sequence, compared to variant 1. The resulting protein (isoform b) has the same N- and C- termini but is shorter when it is compared to isoform a.
    Source sequence(s)
    AK222613, BC008799, DA716772
    Consensus CDS
    CCDS8197.1
    UniProtKB/Swiss-Prot
    Q14247
    UniProtKB/TrEMBL
    A0A024R5M3, Q53HG7
    Related
    ENSP00000317189.4, ENST00000346329.7
    Conserved Domains (4) summary
    cd11959
    Location:459511
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam02218
    Location:231266
    HS1_rep; Repeat in HS1/Cortactin
    pfam15927
    Location:322359
    Casc1_N; Cancer susceptibility candidate 1 N-terminus
    cl26557
    Location:310445
    RNase_E_G; Ribonuclease E/G family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    70398506..70436584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718447.3XP_006718510.1  src substrate cortactin isoform X1

    Conserved Domains (3) summary
    cd11959
    Location:422474
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam02218
    Location:157192
    HS1_rep; Repeat in HS1/Cortactin
    cl05005
    Location:251326
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. XM_006718448.4XP_006718511.1  src substrate cortactin isoform X2

    Conserved Domains (1) summary
    pfam02218
    Location:231266
    HS1_rep; Repeat in HS1/Cortactin
  3. XM_017017312.2XP_016872801.1  src substrate cortactin isoform X3

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160005.1 Reference GRCh38.p13 PATCHES

    Range
    159794..197872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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