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Ctbp2 C-terminal binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 13017, updated on 22-Nov-2022

Summary

Official Symbol
Ctbp2provided by MGI
Official Full Name
C-terminal binding protein 2provided by MGI
Primary source
MGI:MGI:1201686
See related
Ensembl:ENSMUSG00000030970 AllianceGenome:MGI:1201686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ribeye; Gtrgeo6; D7Ertd45e
Summary
Enables several functions, including retinoic acid receptor binding activity; transcription coactivator activity; and transcription corepressor activity. A structural constituent of presynaptic active zone. Involved in negative regulation of transcription, DNA-templated; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of chromatin binding activity; and positive regulation of retinoic acid receptor signaling pathway. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Part of transcription repressor complex. Is active in presynaptic active zone cytoplasmic component and presynaptic cytosol. Is expressed in several structures, including alimentary system; limb; lung; nervous system; and retina layer. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 16.7), CNS E14 (RPKM 16.5) and 27 other tissues See more
Orthologs
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Genomic context

See Ctbp2 in Genome Data Viewer
Location:
7 F3; 7 76.32 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (132588727..132725908, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132986998..133124009, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500002F19 gene Neighboring gene predicted gene 45502 Neighboring gene zinc finger, RAN-binding domain containing 1 Neighboring gene RIKEN cDNA 4932437C15 gene Neighboring gene RIKEN cDNA 4930483O08 gene Neighboring gene predicted gene, 35364 Neighboring gene predicted gene, 35567

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transcription coregulator binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coregulator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle docking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle docking IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in photoreceptor ribbon synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-terminal-binding protein 2
Names
gene trap ROSA b-geo 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170744.2NP_001164215.1  C-terminal-binding protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC119806
    Consensus CDS
    CCDS52417.1
    UniProtKB/Swiss-Prot
    P56546
    Related
    ENSMUSP00000130294.2, ENSMUST00000169570.8
    Conserved Domains (2) summary
    COG0111
    Location:593903
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:577895
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. NM_001347623.2NP_001334552.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1. Variants 3 and 13-19 all encode the same isoform (3).
    Source sequence(s)
    AC119806, AC138624
    Consensus CDS
    CCDS90344.1
    UniProtKB/TrEMBL
    Q91YZ2
    Related
    ENSMUSP00000127448.2, ENSMUST00000166439.8
    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. NM_001412294.1NP_001399223.1  C-terminal-binding protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC119806
  4. NM_001412295.1NP_001399224.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  5. NM_001412296.1NP_001399225.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  6. NM_001412297.1NP_001399226.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  7. NM_001412298.1NP_001399227.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  8. NM_001412299.1NP_001399228.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  9. NM_001412300.1NP_001399229.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  10. NM_001412301.1NP_001399230.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  11. NM_001412302.1NP_001399231.1  C-terminal-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/Swiss-Prot
    O88462
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
  12. NM_001412303.1NP_001399232.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/TrEMBL
    Q91YZ2
  13. NM_001412304.1NP_001399233.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/TrEMBL
    Q91YZ2
  14. NM_001412305.1NP_001399234.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/TrEMBL
    Q91YZ2
  15. NM_001412306.1NP_001399235.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/TrEMBL
    Q91YZ2
  16. NM_001412307.1NP_001399236.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/TrEMBL
    Q91YZ2
  17. NM_001412308.1NP_001399237.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/TrEMBL
    Q91YZ2
  18. NM_001412309.1NP_001399238.1  C-terminal-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119806, AC138624
    UniProtKB/TrEMBL
    Q91YZ2
  19. NM_009980.5NP_034110.1  C-terminal-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_034110.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Variants 2 and 5-12 all encode the same isoform (2).
    Source sequence(s)
    AC119806, AC138624
    Consensus CDS
    CCDS21930.1
    UniProtKB/Swiss-Prot
    O88462, P56546
    UniProtKB/TrEMBL
    A0A8C6HXP1, Q3UGL5
    Related
    ENSMUSP00000033269.9, ENSMUST00000033269.15
    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    132588727..132725908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507308.5XP_006507371.1  C-terminal-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P56546
    UniProtKB/TrEMBL
    Q3UGL5
    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  2. XM_030242066.2XP_030097926.1  C-terminal-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  3. XM_030242064.2XP_030097924.1  C-terminal-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  4. XM_006507309.5XP_006507372.1  C-terminal-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P56546
    UniProtKB/TrEMBL
    Q3UGL5
    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  5. XM_030242065.2XP_030097925.1  C-terminal-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  6. XM_030242069.2XP_030097929.1  C-terminal-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  7. XM_030242068.2XP_030097928.1  C-terminal-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  8. XM_036152631.1XP_036008524.1  C-terminal-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  9. XM_030242067.2XP_030097927.1  C-terminal-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  10. XM_006507310.4XP_006507373.1  C-terminal-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P56546
    UniProtKB/TrEMBL
    Q3UGL5
    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  11. XM_030242070.2XP_030097930.1  C-terminal-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  12. XM_006507311.4XP_006507374.1  C-terminal-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P56546
    UniProtKB/TrEMBL
    Q3UGL5
    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  13. XM_006507312.4XP_006507375.1  C-terminal-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P56546
    UniProtKB/TrEMBL
    Q3UGL5
    Conserved Domains (1) summary
    cd05299
    Location:34352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
  14. XM_036152630.1XP_036008523.1  C-terminal-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    Q91YZ2
    Conserved Domains (1) summary
    cd05299
    Location:9327
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor