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ZNF280A zinc finger protein 280A [ Homo sapiens (human) ]

Gene ID: 129025, updated on 23-Jun-2022

Summary

Official Symbol
ZNF280Aprovided by HGNC
Official Full Name
zinc finger protein 280Aprovided by HGNC
Primary source
HGNC:HGNC:18597
See related
Ensembl:ENSG00000169548 AllianceGenome:HGNC:18597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUHW1; ZNF280; ZNF636; 3'OY11.1
Summary
This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]
Orthologs
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Genomic context

See ZNF280A in Genome Data Viewer
Location:
22q11.22
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (22513736..22520270, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (22936586..22943141, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22868060..22874613, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene immunoglobulin lambda variable 7-35 (pseudogene) Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC648691 Neighboring gene zinc finger protein 280B Neighboring gene IGL region enhancer-blocking element 22-2 Neighboring gene PRAME nuclear receptor transcriptional regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 280A
Names
suppressor of hairy wing homolog 1
zinc finger protein 280
zinc finger protein 636

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000002.1 

    Range
    492048..498612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080740.5NP_542778.2  zinc finger protein 280A

    See identical proteins and their annotated locations for NP_542778.2

    Status: REVIEWED

    Source sequence(s)
    AC246793, BC053901, BP283207
    Consensus CDS
    CCDS13800.1
    UniProtKB/Swiss-Prot
    P59817
    UniProtKB/TrEMBL
    A0A0G2JN84
    Related
    ENSP00000302855.3, ENST00000302097.3
    Conserved Domains (2) summary
    sd00017
    Location:336357
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13836
    Location:47217
    DUF4195; Domain of unknown function (DUF4195)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    22513736..22520270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187629.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    149393..155927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    22936586..22943141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)