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Cox8a cytochrome c oxidase subunit 8A [ Mus musculus (house mouse) ]

Gene ID: 12868, updated on 1-Mar-2024

Summary

Official Symbol
Cox8aprovided by MGI
Official Full Name
cytochrome c oxidase subunit 8Aprovided by MGI
Primary source
MGI:MGI:105959
See related
Ensembl:ENSMUSG00000035885 AllianceGenome:MGI:105959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX8L
Summary
Predicted to enable cytochrome-c oxidase activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; liver; nervous system; nose; and urinary system. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX8A (cytochrome c oxidase subunit 8A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 1660.4), colon adult (RPKM 1505.4) and 27 other tissues See more
Orthologs
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Genomic context

See Cox8a in Genome Data Viewer
Location:
19 A; 19 5.28 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7192523..7194981, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7215158..7217616, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene predicted gene, 38621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7238874-7239062 Neighboring gene OTU domain, ubiquitin aldehyde binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E8735 Neighboring gene STARR-positive B cell enhancer ABC_E11671 Neighboring gene STARR-positive B cell enhancer ABC_E8736 Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene predicted gene, 22113

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cytochrome c oxidase subunit 8A, mitochondrial
Names
COX VIII-L
cytochrome c oxidase polypeptide VIII-liver
cytochrome c oxidase subunit 8-2
cytochrome c oxidase subunit VIIIa
NP_031776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007750.2NP_031776.1  cytochrome c oxidase subunit 8A, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031776.1

    Status: VALIDATED

    Source sequence(s)
    AAHY01141457, AK002218
    Consensus CDS
    CCDS29521.1
    UniProtKB/Swiss-Prot
    Q0VBB1, Q545I2, Q64445
    Related
    ENSMUSP00000040717.5, ENSMUST00000039758.6
    Conserved Domains (1) summary
    pfam02285
    Location:2767
    COX8; Cytochrome oxidase c subunit VIII

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7192523..7194981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)