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Cox7a1 cytochrome c oxidase subunit 7A1 [ Mus musculus (house mouse) ]

Gene ID: 12865, updated on 7-May-2024

Summary

Official Symbol
Cox7a1provided by MGI
Official Full Name
cytochrome c oxidase subunit 7A1provided by MGI
Primary source
MGI:MGI:1316714
See related
Ensembl:ENSMUSG00000074218 AllianceGenome:MGI:1316714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX7A; COX7AH; COX7AM
Summary
Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrion. Is expressed in embryo; heart; lung; metanephros; and skeletal muscle. Used to study dilated cardiomyopathy. Orthologous to human COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 444.7), large intestine adult (RPKM 31.1) and 2 other tissues See more
Orthologs
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Genomic context

See Cox7a1 in Genome Data Viewer
Location:
7 B1; 7 17.31 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29883596..29885455)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30184171..30186030)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18509 Neighboring gene zinc finger protein 146 Neighboring gene predicted gene 5113 Neighboring gene STARR-positive B cell enhancer ABC_E4914 Neighboring gene predicted gene, 53356 Neighboring gene STARR-seq mESC enhancer starr_18511 Neighboring gene calpain, small subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E6531 Neighboring gene STARR-positive B cell enhancer ABC_E6532 Neighboring gene STARR-seq mESC enhancer starr_18512 Neighboring gene STARR-positive B cell enhancer ABC_E4915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31016881-31016990 Neighboring gene tubulin folding cofactor B Neighboring gene polymerase (RNA) II (DNA directed) polypeptide I

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytochrome-c oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial respirasome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 7A1, mitochondrial
Names
cytochrome c oxidase subunit VIIa 1
cytochrome c oxidase subunit VIIa-H
cytochrome c oxidase subunit VIIa-M
cytochrome c oxidase subunit VIIa-heart
cytochrome c oxidase subunit VIIa-muscle
NP_001399200.1
NP_034074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412271.1NP_001399200.1  cytochrome c oxidase subunit 7A1, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164703
    UniProtKB/TrEMBL
    A0A140LIU4
    Related
    ENSMUSP00000146960.2, ENSMUST00000208441.2
  2. NM_009944.3NP_034074.1  cytochrome c oxidase subunit 7A1, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_034074.1

    Status: VALIDATED

    Source sequence(s)
    AK079950, BC060974
    Consensus CDS
    CCDS21081.1
    UniProtKB/Swiss-Prot
    P56392
    UniProtKB/TrEMBL
    Q792A4
    Related
    ENSMUSP00000096193.3, ENSMUST00000098594.4
    Conserved Domains (1) summary
    cd00928
    Location:2276
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29883596..29885455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)