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COX7A1 cytochrome c oxidase subunit 7A1 [ Homo sapiens (human) ]

Gene ID: 1346, updated on 1-Jun-2020

Summary

Official Symbol
COX7A1provided by HGNC
Official Full Name
cytochrome c oxidase subunit 7A1provided by HGNC
Primary source
HGNC:HGNC:2287
See related
Ensembl:ENSG00000161281 MIM:123995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX7A; COX7AH; COX7AM
Summary
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 146.2), fat (RPKM 68.9) and 5 other tissues See more
Orthologs

Genomic context

See COX7A1 in Genome Data Viewer
Location:
19q13.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36150922..36152447, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36641824..36643771, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372385 Neighboring gene calpain small subunit 1 Neighboring gene zinc finger protein 565 Neighboring gene uncharacterized LOC107985304 Neighboring gene zinc finger protein 146 Neighboring gene uncharacterized LOC100134317

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
mitochondrial respiratory chain supercomplex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial respiratory chain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 7A1, mitochondrial
Names
cytochrome c oxidase subunit VIIa heart/muscle isoform
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
cytochrome c oxidase subunit VIIa-H
cytochrome c oxidase subunit VIIa-M
cytochrome c oxidase subunit VIIa-heart
cytochrome c oxidase subunit VIIa-muscle
NP_001855.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001864.4NP_001855.1  cytochrome c oxidase subunit 7A1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001855.1

    Status: REVIEWED

    Source sequence(s)
    BC002757
    Consensus CDS
    CCDS12490.1
    UniProtKB/Swiss-Prot
    P24310
    UniProtKB/TrEMBL
    Q6FGI7
    Related
    ENSP00000292907.3, ENST00000292907.8
    Conserved Domains (1) summary
    cd00928
    Location:2276
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    36150922..36152447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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