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ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide [ Homo sapiens (human) ]

Gene ID: 128, updated on 5-Nov-2019

Summary

Official Symbol
ADH5provided by HGNC
Official Full Name
alcohol dehydrogenase 5 (class III), chi polypeptideprovided by HGNC
Primary source
HGNC:HGNC:253
See related
Ensembl:ENSG00000197894 MIM:103710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FDH; ADHX; ADH-3; FALDH; GSNOR; GSH-FDH; HEL-S-60p
Summary
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in endometrium (RPKM 69.1), kidney (RPKM 68.7) and 25 other tissues See more
Orthologs

Genomic context

See ADH5 in Genome Data Viewer
Location:
4q23
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (99070978..99088788, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99992129..100009931, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 3684 Neighboring gene methionyl aminopeptidase 1 Neighboring gene activator of basal transcription 1 pseudogene 1 Neighboring gene ADH5 promoter Neighboring gene uncharacterized LOC100507053 Neighboring gene Sharpr-MPRA regulatory region 12553 Neighboring gene ADH4 promoter Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
NHGRI GWA Catalog
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
S-(hydroxymethyl)glutathione dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-(hydroxymethyl)glutathione dehydrogenase activity TAS
Traceable Author Statement
more info
PubMed 
alcohol dehydrogenase activity, zinc-dependent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
formaldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
ethanol oxidation TAS
Traceable Author Statement
more info
 
fatty acid omega-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
formaldehyde catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-cysteine S-nitrosylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
respiratory system process IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to nitrosative stress IEA
Inferred from Electronic Annotation
more info
 
response to redox state IDA
Inferred from Direct Assay
more info
PubMed 
retinoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alcohol dehydrogenase class-3
Names
S-(hydroxymethyl)glutathione dehydrogenase
S-nitrosoglutathione reductase
alcohol dehydrogenase (class III), chi polypeptide
alcohol dehydrogenase class chi chain
alcohol dehydrogenase class-III
epididymis secretory sperm binding protein Li 60p
formaldehyde dehydrogenase
glutathione-dependent formaldehyde dehydrogenase
NP_000662.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000671.4NP_000662.3  alcohol dehydrogenase class-3

    See identical proteins and their annotated locations for NP_000662.3

    Status: REVIEWED

    Source sequence(s)
    AC019131, DA737788, M30471
    Consensus CDS
    CCDS47111.1
    UniProtKB/Swiss-Prot
    P11766
    UniProtKB/TrEMBL
    Q6IRT1
    Related
    ENSP00000296412.8, ENST00000296412.13
    Conserved Domains (1) summary
    cd08300
    Location:6373
    alcohol_DH_class_III; class III alcohol dehydrogenases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    99070978..99088788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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