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Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11532, updated on 10-Jun-2024

Summary

Official Symbol
Adh5provided by MGI
Official Full Name
alcohol dehydrogenase 5 (class III), chi polypeptideprovided by MGI
Primary source
MGI:MGI:87929
See related
Ensembl:ENSMUSG00000028138 AllianceGenome:MGI:87929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adh3; Adh-5; GSNOR
Summary
Enables S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD+) activity; and identical protein binding activity. Acts upstream of or within several processes, including formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; and response to lipopolysaccharide. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 86.3), CNS E11.5 (RPKM 59.7) and 25 other tissues See more
Orthologs
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Genomic context

See Adh5 in Genome Data Viewer
Location:
3 G3; 3 64.26 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138142961..138161260)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138437200..138455499)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 6 (class V), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_09107 Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide Neighboring gene STARR-seq mESC enhancer starr_09108 Neighboring gene STARR-positive B cell enhancer ABC_E6139 Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553 Neighboring gene microRNA 1956 Neighboring gene eukaryotic translation initiation factor 4E

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
enables S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
enables alcohol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alcohol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables formaldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alcohol dehydrogenase class-3
Names
ADH-B2
FALDH
FDH
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase
S-nitrosoglutathione reductase
alcohol dehydrogenase 2
alcohol dehydrogenase B2
alcohol dehydrogenase class-III
glutathione-dependent formaldehyde dehydrogenase
NP_001275507.1
NP_031436.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288578.1NP_001275507.1  alcohol dehydrogenase class-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, which results in translation intiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK076507, CF172597
    UniProtKB/Swiss-Prot
    P28474
    Conserved Domains (1) summary
    cl16912
    Location:1251
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
  2. NM_007410.3NP_031436.2  alcohol dehydrogenase class-3 isoform 1

    See identical proteins and their annotated locations for NP_031436.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK076507, BY125542
    Consensus CDS
    CCDS17868.1
    UniProtKB/Swiss-Prot
    P28474, Q3TW83, Q8C662
    UniProtKB/TrEMBL
    Q6P5I3
    Related
    ENSMUSP00000005964.3, ENSMUST00000005964.7
    Conserved Domains (2) summary
    cd08300
    Location:6373
    alcohol_DH_class_III; class III alcohol dehydrogenases
    COG1062
    Location:6374
    FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    138142961..138161260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)