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Ccr2 chemokine (C-C motif) receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 12772, updated on 31-Jan-2023

Summary

Official Symbol
Ccr2provided by MGI
Official Full Name
chemokine (C-C motif) receptor 2provided by MGI
Primary source
MGI:MGI:106185
See related
Ensembl:ENSMUSG00000049103 AllianceGenome:MGI:106185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2
Summary
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including leukocyte migration; positive regulation of cell migration; and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and neutrophil clearance. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif chemokine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 3.5), mammary gland adult (RPKM 3.2) and 17 other tissues See more
Orthologs
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Genomic context

See Ccr2 in Genome Data Viewer
Location:
9 F4; 9 75.05 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123901954..123913594)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (124101918..124109140)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) receptor 1-like 1 Neighboring gene chemokine (C-C motif) receptor 3 Neighboring gene chemokine (C-C motif) receptor 5 Neighboring gene predicted gene, 39469

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables chemokine (C-C motif) ligand 12 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chemokine (C-C motif) ligand 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chemokine (C-C motif) ligand 5 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine (C-C motif) ligand 7 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 17 cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic cell clearance IC
Inferred by Curator
more info
PubMed 
involved_in blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of eosinophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CD8-positive, alpha-beta T cell extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 1 cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of astrocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immune complex clearance by monocytes and macrophages IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of thymocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of macrophage migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mononuclear cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing involved in inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in primary dendrite ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-C chemokine receptor type 2
Names
C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
C-C CKR-2
CCR-2
JE/FIC receptor
MCP-1 receptor
MIP-1 alphaR
chemoattractant protein-1 receptor
chemokine (C-C) receptor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009915.2NP_034045.1  C-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_034045.1

    Status: VALIDATED

    Source sequence(s)
    AK138599, AK162705, U56819
    Consensus CDS
    CCDS23669.1
    UniProtKB/Swiss-Prot
    P51683, Q61172
    UniProtKB/TrEMBL
    Q3TRK1, Q543S8
    Related
    ENSMUSP00000049909.7, ENSMUST00000055918.7
    Conserved Domains (1) summary
    cd15184
    Location:57329
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    123901954..123913594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154587.1XP_036010480.1  C-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    Q61172
    UniProtKB/TrEMBL
    Q543S8
    Related
    ENSMUSP00000130112.2, ENSMUST00000171719.8
    Conserved Domains (1) summary
    cd15184
    Location:57329
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011243063.2XP_011241365.1  C-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_011241365.1

    UniProtKB/Swiss-Prot
    P51683, Q61172
    UniProtKB/TrEMBL
    Q543S8
    Conserved Domains (1) summary
    cd15184
    Location:57329
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_036154586.1XP_036010479.1  C-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    Q61172
    UniProtKB/TrEMBL
    Q543S8
    Conserved Domains (1) summary
    cd15184
    Location:57329
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_036154585.1XP_036010478.1  C-C chemokine receptor type 2 isoform X1

    UniProtKB/Swiss-Prot
    Q61172
    UniProtKB/TrEMBL
    Q543S8
    Conserved Domains (1) summary
    cd15184
    Location:57329
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_011243064.4XP_011241366.1  C-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_011241366.1

    UniProtKB/Swiss-Prot
    P51683, Q61172
    UniProtKB/TrEMBL
    Q543S8
    Related
    ENSMUSP00000132453.2, ENSMUST00000168841.3
    Conserved Domains (1) summary
    cd15184
    Location:57329
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_006512428.3XP_006512491.1  C-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_006512491.1

    UniProtKB/Swiss-Prot
    P51683, Q61172
    UniProtKB/TrEMBL
    Q543S8
    Conserved Domains (1) summary
    cd15184
    Location:57329
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors