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CCR2 C-C motif chemokine receptor 2 [ Homo sapiens (human) ]

Gene ID: 729230, updated on 3-Jun-2018
Official Symbol
CCR2provided by HGNC
Official Full Name
C-C motif chemokine receptor 2provided by HGNC
Primary source
HGNC:HGNC:1603
See related
Ensembl:ENSG00000121807 MIM:601267; Vega:OTTHUMG00000156466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
Summary
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
Expression
Biased expression in appendix (RPKM 15.2), lymph node (RPKM 5.1) and 12 other tissues See more
Orthologs
See CCR2 in Genome Data Viewer
Location:
3p21.31
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (46353744..46360940)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46395235..46402413)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 3 Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1 Neighboring gene uncharacterized LOC102724297 Neighboring gene C-C motif chemokine receptor 5 (gene/pseudogene) Neighboring gene C-C motif chemokine receptor like 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
NHGRI GWA Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
HIV/tuberculosis coinfection upregulates CCR2 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis) PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of the resting CD4+ T cells with HIV-1 clade B Tat, but not clade C Tat, increases surface CXCR4 expression, which leads to increased function of CXCR4 including increased chemoattraction toward CXCR4-using-gp120 PubMed
env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
env HIV-1 gp120 from CXCR4-tropic subtype E viruses isolated in Thailand associates with and uses at least one of the following coreceptors for virus entry: CCR8, CCR1, CCR2b, or CX3CR1 PubMed
Nef nef HIV-1 Nef induces variable levels of CCR2 downregulation in different cell types PubMed
Tat tat HIV-1 Tat upregulates the expression of CCR2,CD16, and TLR-4 in monocyte-derived macrophages PubMed
tat HIV-1 clade B Tat, but not clade C Tat, increases CXCR4 surface expression on resting CD4+ T cells through a CCR2b-dependent mechanism that does not involve de novo protein synthesis PubMed
tat HIV-1 Tat induces CCR2-mediated glial activation PubMed
tat Results from the treatment of microglia with HIV-1 Tat suggest downregulation of CCR2 mRNA expression by HIV-1 Tat, however this was deemed to not be significant PubMed
tat HIV-1 Tat binds to CCR2 and displaces MCP-1 from this beta-chemokine receptor, an effect mediated by Tat amino acids 24-51 PubMed

Go to the HIV-1, Human Interaction Database

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • Beta defensins, organism-specific biosystem (from REACTOME)
    Beta defensins, organism-specific biosystemHumans have 38 beta-defensin genes plus 9-10 pseudogenes (details available on the HGNC website at http://www.genenames.org/genefamilies/DEFB). Many beta-defensins are encoded by recently duplicated ...
  • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
    Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Defensins, organism-specific biosystem (from REACTOME)
    Defensins, organism-specific biosystemThe defensins are a family of antimicrobial cationic peptide molecules which in mammals have a characteristic beta-sheet-rich fold and framework of six disulphide-linked cysteines (Selsted & Ouellet...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-10 signaling, organism-specific biosystemInterleukin-10 (IL10) was originally described as a factor named cytokine synthesis inhibitory factor that inhibited T-helper (Th) 1 activation and Th1 cytokine production (Fiorentino et al. 1989). ...
  • Lung fibrosis, organism-specific biosystem (from WikiPathways)
    Lung fibrosis, organism-specific biosystemLung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis.
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ78302, MGC103828, MGC111760, MGC168006

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
CCR2 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
chemokine (C-C motif) ligand 12 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine (C-C motif) ligand 12 binding IEA
Inferred from Electronic Annotation
more info
 
chemokine (C-C motif) ligand 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine (C-C motif) ligand 2 binding IEA
Inferred from Electronic Annotation
more info
 
chemokine (C-C motif) ligand 7 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine (C-C motif) ligand 7 binding IEA
Inferred from Electronic Annotation
more info
 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
T-helper 17 cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular defense response IEA
Inferred from Electronic Annotation
more info
 
cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendritic cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
humoral immune response IEA
Inferred from Electronic Annotation
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
leukocyte adhesion to vascular endothelial cell IEA
Inferred from Electronic Annotation
more info
 
monocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of eosinophil degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of type 2 immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil clearance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of CD8-positive, alpha-beta T cell extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 1 type immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of alpha-beta T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of astrocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of hematopoietic stem cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immune complex clearance by monocytes and macrophages ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of monocyte extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tumor necrosis factor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
C-C chemokine receptor type 2
Names
MCP-1 receptor
chemokine (C-C motif) receptor 2
monocyte chemoattractant protein 1 receptor
monocyte chemotactic protein 1 receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021428.1 RefSeqGene

    Range
    5001..12179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001123041.2NP_001116513.2  C-C chemokine receptor type 2 isoform A

    See identical proteins and their annotated locations for NP_001116513.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AV715904, BC126452, BQ027284, BX101672, DC401093, DC418358
    Consensus CDS
    CCDS43078.1
    UniProtKB/Swiss-Prot
    P41597
    Related
    ENSP00000292301.3, ENST00000292301.4
    Conserved Domains (1) summary
    cd15184
    Location:43316
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001123396.2NP_001116868.1  C-C chemokine receptor type 2 isoform B

    See identical proteins and their annotated locations for NP_001116868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 3' UTR and 3' coding region, compared to variant A. The resulting isoform (B) is shorter and contains a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC098613, AC138069
    Consensus CDS
    CCDS46813.1
    UniProtKB/Swiss-Prot
    P41597
    UniProtKB/TrEMBL
    A0A024R2Q0
    Related
    ENSP00000399285.2, OTTHUMP00000209948, ENST00000445132.2
    Conserved Domains (2) summary
    pfam00001
    Location:59305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam06417
    Location:245283
    DUF1077; Protein of unknown function (DUF1077)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    46353744..46360940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534069.1XP_011532371.1  C-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_011532371.1

    UniProtKB/Swiss-Prot
    P41597
    UniProtKB/TrEMBL
    A0A024R2Q0
    Conserved Domains (2) summary
    pfam00001
    Location:59305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam06417
    Location:245283
    DUF1077; Protein of unknown function (DUF1077)
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