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CCR2 C-C motif chemokine receptor 2 [ Homo sapiens (human) ]

Gene ID: 729230, updated on 19-Sep-2021

Summary

Official Symbol
CCR2provided by HGNC
Official Full Name
C-C motif chemokine receptor 2provided by HGNC
Primary source
HGNC:HGNC:1603
See related
Ensembl:ENSG00000121807 MIM:601267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
Summary
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
Expression
Biased expression in appendix (RPKM 15.2), lymph node (RPKM 5.1) and 12 other tissues See more
Orthologs
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Genomic context

See CCR2 in Genome Data Viewer
Location:
3p21.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (46354111..46360940)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46395602..46402431)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 3 Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1 Neighboring gene CCR5 antisense RNA Neighboring gene C-C motif chemokine receptor 5 Neighboring gene C-C motif chemokine receptor like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
GeneReviews: Not available
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
GeneReviews: Not available
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV/tuberculosis coinfection upregulates CCR2 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis) PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of the resting CD4+ T cells with HIV-1 clade B Tat, but not clade C Tat, increases surface CXCR4 expression, which leads to increased function of CXCR4 including increased chemoattraction toward CXCR4-using-gp120 PubMed
env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
env HIV-1 gp120 from CXCR4-tropic subtype E viruses isolated in Thailand associates with and uses at least one of the following coreceptors for virus entry: CCR8, CCR1, CCR2b, or CX3CR1 PubMed
Nef nef HIV-1 Nef induces variable levels of CCR2 downregulation in different cell types PubMed
Tat tat HIV-1 Tat upregulates the expression of CCR2,CD16, and TLR-4 in monocyte-derived macrophages PubMed
tat HIV-1 clade B Tat, but not clade C Tat, increases CXCR4 surface expression on resting CD4+ T cells through a CCR2b-dependent mechanism that does not involve de novo protein synthesis PubMed
tat HIV-1 Tat induces CCR2-mediated glial activation PubMed
tat Results from the treatment of microglia with HIV-1 Tat suggest downregulation of CCR2 mRNA expression by HIV-1 Tat, however this was deemed to not be significant PubMed
tat HIV-1 Tat binds to CCR2 and displaces MCP-1 from this beta-chemokine receptor, an effect mediated by Tat amino acids 24-51 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ78302, MGC103828, MGC111760, MGC168006

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR2 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine (C-C motif) ligand 12 binding IEA
Inferred from Electronic Annotation
more info
 
enables chemokine (C-C motif) ligand 2 binding IEA
Inferred from Electronic Annotation
more info
 
enables chemokine (C-C motif) ligand 7 binding IEA
Inferred from Electronic Annotation
more info
 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in T-helper 17 cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chemotaxis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
involved_in humoral immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leukocyte adhesion to vascular endothelial cell IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in monocyte extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of eosinophil degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of type 2 immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neutrophil clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of CD8-positive, alpha-beta T cell extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NMDA glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T-helper 1 type immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of alpha-beta T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of astrocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of hematopoietic stem cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of immune complex clearance by monocytes and macrophages ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of monocyte extravasation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of thymocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of T cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to wounding TAS
Traceable Author Statement
more info
PubMed 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-C chemokine receptor type 2
Names
MCP-1 receptor
chemokine (C-C motif) receptor 2
monocyte chemoattractant protein 1 receptor
monocyte chemotactic protein 1 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021428.1 RefSeqGene

    Range
    5001..12179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001123041.3NP_001116513.2  C-C chemokine receptor type 2 isoform A

    See identical proteins and their annotated locations for NP_001116513.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AC098613, AV715904, BC126452, BQ027284, BX101672, DC418358
    Consensus CDS
    CCDS43078.1
    UniProtKB/Swiss-Prot
    P41597
    Related
    ENSP00000383681.2, ENST00000400888.2
    Conserved Domains (1) summary
    cd15184
    Location:43316
    7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001123396.4NP_001116868.1  C-C chemokine receptor type 2 isoform B

    See identical proteins and their annotated locations for NP_001116868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 3' UTR and 3' coding region, compared to variant A. The resulting isoform (B) is shorter and contains a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC098613, AC138069
    Consensus CDS
    CCDS46813.1
    UniProtKB/Swiss-Prot
    P41597
    UniProtKB/TrEMBL
    A0A024R2Q0
    Related
    ENSP00000399285.2, ENST00000445132.3
    Conserved Domains (2) summary
    pfam00001
    Location:59305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam06417
    Location:245283
    DUF1077; Protein of unknown function (DUF1077)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    46354111..46360940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534069.1XP_011532371.1  C-C chemokine receptor type 2 isoform X1

    See identical proteins and their annotated locations for XP_011532371.1

    UniProtKB/Swiss-Prot
    P41597
    UniProtKB/TrEMBL
    A0A024R2Q0
    Conserved Domains (2) summary
    pfam00001
    Location:59305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam06417
    Location:245283
    DUF1077; Protein of unknown function (DUF1077)
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