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Cxcr4 chemokine (C-X-C motif) receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 12767, updated on 4-Jul-2019

Summary

Official Symbol
Cxcr4provided by MGI
Official Full Name
chemokine (C-X-C motif) receptor 4provided by MGI
Primary source
MGI:MGI:109563
See related
Ensembl:ENSMUSG00000045382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
Expression
Biased expression in thymus adult (RPKM 230.6), spleen adult (RPKM 93.9) and 10 other tissues See more
Orthologs

Genomic context

See Cxcr4 in Genome Data Viewer
Location:
1 E3; 1 56.43 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (128588199..128592311, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (130484776..130488876, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 41950 Neighboring gene thrombospondin, type I, domain containing 7B Neighboring gene predicted gene, 36347 Neighboring gene nucleoporin 54 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
C-X-C motif chemokine 12 receptor activity ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
cytokine binding IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
myosin light chain binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
CXCL12-activated CXCR4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ameboidal-type cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
detection of temperature stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
generation of neurons IEP
Inferred from Expression Pattern
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neural precursor cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurogenesis ISO
Inferred from Sequence Orthology
more info
 
neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage migration inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal stem cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
regulation of viral process ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
telencephalon cell migration ISO
Inferred from Sequence Orthology
more info
 
ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 4
Names
SDF-1 receptor
chemokine (C-X-C) receptor 4
chemokine receptor 4
fusin
leukocyte-derived seven transmembrane domain receptor
leukocyte-expressed seven-transmembrane-domain
pre-B-cell-derived chemokine receptor
stromal cell-derived factor 1 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356509.1NP_001343438.1  C-X-C chemokine receptor type 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161170
    Conserved Domains (2) summary
    pfam12109
    Location:638
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    cd15179
    Location:39318
    7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_009911.3NP_034041.2  C-X-C chemokine receptor type 4 isoform 1

    See identical proteins and their annotated locations for NP_034041.2

    Status: VALIDATED

    Source sequence(s)
    AB000803, BB872868, BF662224
    Consensus CDS
    CCDS15254.1
    UniProtKB/Swiss-Prot
    P70658
    UniProtKB/TrEMBL
    A0A0R4J0N8
    Related
    ENSMUSP00000053489.6, ENSMUST00000052172.6
    Conserved Domains (2) summary
    pfam00001
    Location:57309
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam12109
    Location:840
    CXCR4_N; CXCR4 Chemokine receptor N terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    128588199..128592311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529113.3XP_006529176.1  C-X-C chemokine receptor type 4 isoform X1

    Conserved Domains (2) summary
    pfam12109
    Location:638
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    cd15179
    Location:39318
    7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_006529114.2XP_006529177.1  C-X-C chemokine receptor type 4 isoform X2

    Conserved Domains (2) summary
    pfam00001
    Location:54306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam12109
    Location:537
    CXCR4_N; CXCR4 Chemokine receptor N terminal
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