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Cxcr4 C-X-C motif chemokine receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 12767, updated on 7-Apr-2024

Summary

Official Symbol
Cxcr4provided by MGI
Official Full Name
C-X-C motif chemokine receptor 4provided by MGI
Primary source
MGI:MGI:109563
See related
Ensembl:ENSMUSG00000045382 AllianceGenome:MGI:109563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
Summary
Predicted to enable several functions, including chemokine receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in myelin maintenance; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including circulatory system development; gamete generation; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 230.6), spleen adult (RPKM 93.9) and 10 other tissues See more
Orthologs
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Genomic context

See Cxcr4 in Genome Data Viewer
Location:
1 E4; 1 56.43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (128515936..128520036, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128588199..128592299, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4344 Neighboring gene STARR-positive B cell enhancer ABC_E2558 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130487786-130488065 Neighboring gene STARR-positive B cell enhancer ABC_E10032 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:130502453-130502636 Neighboring gene STARR-positive B cell enhancer ABC_E4345 Neighboring gene STARR-positive B cell enhancer ABC_E10033 Neighboring gene STARR-positive B cell enhancer ABC_E7744 Neighboring gene predicted gene, 41950 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9477 Neighboring gene STARR-seq mESC enhancer starr_02173 Neighboring gene STARR-seq mESC enhancer starr_02174 Neighboring gene STARR-positive B cell enhancer ABC_E2007 Neighboring gene STARR-seq mESC enhancer starr_02175 Neighboring gene STARR-seq mESC enhancer starr_02176 Neighboring gene STARR-seq mESC enhancer starr_02178 Neighboring gene STARR-seq mESC enhancer starr_02179 Neighboring gene predicted gene, 23056 Neighboring gene STARR-seq mESC enhancer starr_02180 Neighboring gene STARR-seq mESC enhancer starr_02181 Neighboring gene STARR-seq mESC enhancer starr_02182 Neighboring gene STARR-seq mESC enhancer starr_02183 Neighboring gene STARR-seq mESC enhancer starr_02184 Neighboring gene thrombospondin, type I, domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_02185 Neighboring gene predicted gene, 36347

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables C-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables C-X-C motif chemokine 12 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin light chain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in CXCL12-activated CXCR4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in generation of neurons IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neural precursor cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mesenchymal stem cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasculature development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tacrolimus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in telencephalon cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 4
Names
SDF-1 receptor
chemokine (C-X-C motif) receptor 4
chemokine (C-X-C) receptor 4
chemokine receptor 4
fusin
leukocyte-derived seven transmembrane domain receptor
leukocyte-expressed seven-transmembrane-domain
pre-B-cell-derived chemokine receptor
stromal cell-derived factor 1 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356509.1NP_001343438.1  C-X-C chemokine receptor type 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161170
    UniProtKB/Swiss-Prot
    O09059, O09062, P70233, P70346, P70658, Q4KMW1
    Conserved Domains (2) summary
    pfam12109
    Location:638
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    cd15179
    Location:39318
    7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001420067.1NP_001406996.1  C-X-C chemokine receptor type 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161170
  3. NM_001420068.1NP_001406997.1  C-X-C chemokine receptor type 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161170
  4. NM_009911.4NP_034041.2  C-X-C chemokine receptor type 4 isoform 1

    See identical proteins and their annotated locations for NP_034041.2

    Status: VALIDATED

    Source sequence(s)
    AC161170
    Consensus CDS
    CCDS15254.1
    UniProtKB/Swiss-Prot
    O09059, O09062, P70233, P70346, P70658, Q4KMW1
    UniProtKB/TrEMBL
    A0A0R4J0N8
    Related
    ENSMUSP00000053489.7, ENSMUST00000052172.7
    Conserved Domains (2) summary
    pfam00001
    Location:57309
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam12109
    Location:840
    CXCR4_N; CXCR4 Chemokine receptor N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    128515936..128520036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)