4RWS


Conserved Protein Domain Family
CXCR4_N

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pfam12109: CXCR4_N (this model, PSSM-Id:288925 is obsolete and has been replaced by 432337)
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CXCR4 Chemokine receptor N terminal
CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1.
Statistics
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PSSM-Id: 288925
Aligned: 9 rows
Threshold Bit Score: 63.9733
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RWS_A        15 IYTSDNYTEE----MGSGDYDSMKEPCFREENANFNK 47 
XP_002198314  20 IELSENGTDE----IGSGDYGDYKEPCYQNENADFNR 52  zebra finch
AAG09054      12 IEFADNGSEE----IGSADYGDYGEPCFQHENADFNR 44  chicken
AAF89362       1 IYTSDNYTEE----LGSGDYDSIKEPCFREENAHFNR 33  black lemur
XP_003215140   9 IFMTENSTDE----PGSGDDGDYQEVCLQQENADFNR 41  green anole
XP_007667673 283 IDIHDNSSDGdwsgSGSGDYDNYKEPCYRQENADFNR 319 platypus
XP_007494171  16 IEFHDNNTVEg---FGSGDYEG-KEPCYPNENEDFNR 48  gray short-tailed opossum
ETE73728       1 M--FDNNTGE----LGSGEEDNFTGLCFEEENEDFNR 31  king cobra
Q07FZ4        10 INIFDSNSTE----NGSGDFEDFSEPCFMHDNSDFNR 42  western clawed frog
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