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Ckmt1 creatine kinase, mitochondrial 1, ubiquitous [ Mus musculus (house mouse) ]

Gene ID: 12716, updated on 10-Jun-2024

Summary

Official Symbol
Ckmt1provided by MGI
Official Full Name
creatine kinase, mitochondrial 1, ubiquitousprovided by MGI
Primary source
MGI:MGI:99441
See related
Ensembl:ENSMUSG00000000308 AllianceGenome:MGI:99441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mt-CK; mi-CK; U-MtCK; mia-CK; ScCKmit; UbCKmit
Summary
Predicted to enable creatine kinase activity and identical protein binding activity. Involved in negative regulation of apoptotic process and negative regulation of protein binding activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; sensory organ; and urinary system. Orthologous to several human genes including CKMT1A (creatine kinase, mitochondrial 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 828.0), duodenum adult (RPKM 727.8) and 6 other tissues See more
Orthologs
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Genomic context

See Ckmt1 in Genome Data Viewer
Location:
2 E5; 2 60.37 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121188257..121194218)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121357773..121363737)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tubulin, gamma complex component 4 Neighboring gene transformation related protein 53 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_05522 Neighboring gene STARR-seq mESC enhancer starr_05523 Neighboring gene STARR-positive B cell enhancer ABC_E2640 Neighboring gene STARR-seq mESC enhancer starr_05524 Neighboring gene STARR-positive B cell enhancer ABC_E5972 Neighboring gene STARR-seq mESC enhancer starr_05525 Neighboring gene microtubule-associated protein 1 A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E640 Neighboring gene predicted gene, 33947 Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene elongation factor RNA polymerase II-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables creatine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner-outer membrane contact site ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
creatine kinase U-type, mitochondrial
Names
acidic-type mitochondrial creatine kinase
ubiquitous mitochondrial creatine kinase
NP_001341998.1
NP_001403881.1
NP_001403882.1
NP_001403883.1
NP_001403884.1
NP_001403885.1
NP_001403886.1
NP_034027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355069.1NP_001341998.1  creatine kinase U-type, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845466
    Consensus CDS
    CCDS16640.1
    UniProtKB/Swiss-Prot
    P30275
    UniProtKB/TrEMBL
    Q545N7
    Related
    ENSMUSP00000077349.3, ENSMUST00000078222.9
    Conserved Domains (1) summary
    cd00716
    Location:50407
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
  2. NM_001416952.1NP_001403881.1  creatine kinase U-type, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845466
    UniProtKB/Swiss-Prot
    P30275
    UniProtKB/TrEMBL
    Q545N7
  3. NM_001416953.1NP_001403882.1  creatine kinase U-type, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845466
  4. NM_001416954.1NP_001403883.1  creatine kinase U-type, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845466
  5. NM_001416955.1NP_001403884.1  creatine kinase U-type, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL845466
  6. NM_001416956.1NP_001403885.1  creatine kinase U-type, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845466
  7. NM_001416957.1NP_001403886.1  creatine kinase U-type, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845466
  8. NM_009897.4NP_034027.1  creatine kinase U-type, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_034027.1

    Status: VALIDATED

    Source sequence(s)
    AL845466
    Consensus CDS
    CCDS16640.1
    UniProtKB/Swiss-Prot
    P30275
    UniProtKB/TrEMBL
    Q545N7
    Related
    ENSMUSP00000000317.6, ENSMUST00000000317.13
    Conserved Domains (1) summary
    cd00716
    Location:50407
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121188257..121194218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)