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CKMT1B creatine kinase, mitochondrial 1B [ Homo sapiens (human) ]

Gene ID: 1159, updated on 7-Jun-2020

Summary

Official Symbol
CKMT1Bprovided by HGNC
Official Full Name
creatine kinase, mitochondrial 1Bprovided by HGNC
Primary source
HGNC:HGNC:1995
See related
Ensembl:ENSG00000237289 MIM:123290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKMT; CKMT1; UMTCK
Summary
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 40.9), duodenum (RPKM 39.5) and 13 other tissues See more
Orthologs

Genomic context

See CKMT1B in Genome Data Viewer
Location:
15q15.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43592857..43599406)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43885055..43891604)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microtubule associated protein 1A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene RNA, U6 small nuclear 554, pseudogene Neighboring gene PPIP5K1P1-CATSPER2 readthrough Neighboring gene stereocilin Neighboring gene cation channel sperm associated 2 Neighboring gene RNA, U6 small nuclear 610, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with creatine kinase, mitochondrial 1B (CKMT1B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
creatine metabolic process TAS
Traceable Author Statement
more info
 
phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
creatine kinase U-type, mitochondrial
Names
U-MtCK
acidic-type mitochondrial creatine kinase
creatine kinase, mitochondrial 1 (ubiquitous)
mia-CK
ubiquitous mitochondrial creatine kinase
NP_001362413.1
NP_066270.1
XP_005254207.1
XP_011519496.1
XP_011519497.1
XP_011519498.1
XP_011519500.1
XP_011519501.2
XP_016877391.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375484.1NP_001362413.1  creatine kinase U-type, mitochondrial precursor

    Status: REVIEWED

    Source sequence(s)
    AC011330
    Related
    ENSP00000413255.1, ENST00000441322.5
  2. NM_020990.4NP_066270.1  creatine kinase U-type, mitochondrial precursor

    See identical proteins and their annotated locations for NP_066270.1

    Status: REVIEWED

    Source sequence(s)
    BC108652, DC307769, DC365843
    Consensus CDS
    CCDS10097.1
    UniProtKB/Swiss-Prot
    P12532
    Related
    ENSP00000300283.6, ENST00000300283.10
    Conserved Domains (1) summary
    cd00716
    Location:49406
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RNA

  1. NR_135748.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011330, AK293790, BC108652, HY128206
  2. NR_135749.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011330, BC108652
  3. NR_135750.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011330, BC108652
  4. NR_135751.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011330, BC108652
    Related
    ENST00000437534.3
  5. NR_135752.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011330, BC108652

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43592857..43599406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521198.1XP_011519500.1  creatine kinase U-type, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_011519500.1

    Conserved Domains (1) summary
    cd00716
    Location:8365
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
  2. XM_017021902.1XP_016877391.1  creatine kinase U-type, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl02823
    Location:4247
    phosphagen_kinases; Phosphagen (guanidino) kinases
  3. XM_011521194.1XP_011519496.1  creatine kinase U-type, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011519496.1

    UniProtKB/Swiss-Prot
    P12532
    Conserved Domains (1) summary
    cd00716
    Location:80437
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
  4. XM_011521199.2XP_011519501.2  creatine kinase U-type, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl02823
    Location:4247
    phosphagen_kinases; Phosphagen (guanidino) kinases
  5. XM_011521196.1XP_011519498.1  creatine kinase U-type, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011519498.1

    UniProtKB/Swiss-Prot
    P12532
    Conserved Domains (1) summary
    cd00716
    Location:80437
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
  6. XM_011521195.2XP_011519497.1  creatine kinase U-type, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011519497.1

    UniProtKB/Swiss-Prot
    P12532
    Conserved Domains (1) summary
    cd00716
    Location:80437
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
  7. XM_005254150.4XP_005254207.1  creatine kinase U-type, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_005254207.1

    Conserved Domains (1) summary
    cl02823
    Location:4247
    phosphagen_kinases; Phosphagen (guanidino) kinases
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