Elovl3 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elovl3provided by MGI
Official Full Name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3provided by MGI
Primary source: MGI:MGI:1195976
See related: Ensembl:ENSMUSG00000038754 AllianceGenome:MGI:1195976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CIN-2; Cig30
Summary: Predicted to enable fatty acid elongase activity. Involved in fatty acid biosynthetic process and positive regulation of cold-induced thermogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in brown fat; embryo; head; and skin. Orthologous to human ELOVL3 (ELOVL fatty acid elongase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 4.2), adrenal adult (RPKM 2.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.75 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (46120336..46124133)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (46131897..46135694)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.
Title: Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.
Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
Title: Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals.
Elovl3 knockout, ELOVL3-ablated (E3hom) mice and their wild type littermates were compared. E3hom mice had abnormal ocular phenotypes such as delayed eye opening, weeping eyes, crusty eyelids, eyelid edema, highly vascularized cornea and tarsal plates (TPs), slit eye, and increased tearing. E3hom TPs had abnormal esters, wax esters, and cholesteryl esters of (O)-acylated w-hydroxy fatty acids.
Title: On the pivotal role of Elovl3/ELOVL3 in meibogenesis and ocular physiology of mice.
lack of either the circadian clock or androgen signaling impairs hepatic Elovl3 expression, highlighting the observation that coordination between the circadian clock and androgen signaling is required to sustain the rhythmic expression of Elovl3 in mouse liver
Title: Coordination between the circadian clock and androgen signaling is required to sustain rhythmic expression of Elovl3 in mouse liver.
Data (including data from studies in knockout mice) suggest signal transduction via calcitriol/calcitriol receptor regulates expression of Elovl3 (fatty acid elongase 3) and alters fatty acid composition in subcutaneous (not visceral) adipose tissue.
Title: Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3.
that ablation of ELOVL3 leads to reduced adiponectin levels, constrained expansion of adipose tissue, and resistance against diet-induced obesity, a situation that is more exaggerated in female mice
Title: Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity.
Elovl3 expression in mouse liver is under strict diurnal control by circulating steroid hormones such as glucocorticoids and androgens
Title: Steroid hormones control circadian Elovl3 expression in mouse liver.
ELOVL3 is an important regulator of endogenous synthesis of saturated very long chain fatty acids and triglyceride formation in brown adipose tissue during the early phase of the tissue recruitment
Title: ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue.
ELOVL3 and fatty acid chain length play roles in development of hair and skin function
Title: Role for ELOVL3 and fatty acid chain length in development of hair and skin function.
The Elovl3 gene upstream region was repressed by RevErbalpha and activated by sterol-regulatory element binding protein-1 (SREBP1) transcription factors.
Title: Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional status.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (1) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

General gene information

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Markers

RH142219 (e-PCR)
- UniSTS:231469

Elovl3 (e-PCR), detects polymorphism
- UniSTS:256820

AF005772 (e-PCR)
- UniSTS:160847

Homology

Homologs of the Elovl3 gene: The Elovl3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 264 organisms have orthologs with human gene Elovl3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid elongase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables fatty acid elongase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables very-long-chain 3-ketoacyl-CoA synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid elongation, monounsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in fatty acid elongation, monounsaturated fatty acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid elongation, monounsaturated fatty acid	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation, polyunsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in fatty acid elongation, polyunsaturated fatty acid	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation, saturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in fatty acid elongation, saturated fatty acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid elongation, saturated fatty acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in very long-chain fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: elongation of very long chain fatty acids protein 3

Names: 3-keto acyl-CoA synthase Elovl3; ELOVL FA elongase 3; ELOVL fatty acid elongase 3; cold inducible glycoprotein 30; cold-inducible glycoprotein of 30 kDa; elongation of very long chain fatty acids-like 3; very long chain 3-ketoacyl-CoA synthase 3; very long chain 3-oxoacyl-CoA synthase 3

NP_001361594.1

EC 2.3.1.199

NP_031729.1

EC 2.3.1.199

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374665.1 → NP_001361594.1 elongation of very long chain fatty acids protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC140233

UniProtKB/TrEMBL

A0A498WFQ4

Related

ENSMUSP00000036357.5, ENSMUST00000043739.6

Conserved Domains (1) summary

pfam01151
Location:29 → 244

ELO; GNS1/SUR4 family
NM_007703.2 → NP_031729.1 elongation of very long chain fatty acids protein 3 isoform 1

See identical proteins and their annotated locations for NP_031729.1

Status: VALIDATED

Source sequence(s)

AA241332, U97107

Consensus CDS

CCDS29871.1

UniProtKB/Swiss-Prot

O35949

UniProtKB/TrEMBL

A0A8C6GZT4

Related

ENSMUSP00000157465.2, ENSMUST00000237098.2

Conserved Domains (1) summary

pfam01151
Location:52 → 267

ELO; GNS1/SUR4 family