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Elovl3 ELOVL fatty acid elongase 3 [ Mus musculus (house mouse) ]

Gene ID: 12686, updated on 1-Mar-2024

Summary

Official Symbol
Elovl3provided by MGI
Official Full Name
ELOVL fatty acid elongase 3provided by MGI
Primary source
MGI:MGI:1195976
See related
Ensembl:ENSMUSG00000038754 AllianceGenome:MGI:1195976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIN-2; Cig30
Summary
Predicted to enable fatty acid elongase activity. Involved in fatty acid biosynthetic process and positive regulation of cold-induced thermogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in brown fat; embryo; head; and skin. Orthologous to human ELOVL3 (ELOVL fatty acid elongase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 4.2), adrenal adult (RPKM 2.3) and 7 other tissues See more
Orthologs
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Genomic context

See Elovl3 in Genome Data Viewer
Location:
19 C3; 19 38.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46120336..46124133)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46131897..46135694)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1527 Neighboring gene STARR-positive B cell enhancer ABC_E7666 Neighboring gene peroxisome proliferative activated receptor, gamma, coactivator-related 1 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene STARR-positive B cell enhancer ABC_E11034 Neighboring gene STARR-positive B cell enhancer ABC_E101 Neighboring gene paired-like homeodomain transcription factor 3 Neighboring gene golgi-specific brefeldin A-resistance factor 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene STARR-seq mESC enhancer starr_46298 Neighboring gene STARR-positive B cell enhancer ABC_E11035 Neighboring gene STARR-seq mESC enhancer starr_46300 Neighboring gene RIKEN cDNA 4833438C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E9457 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (7) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid elongase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid elongation, monounsaturated fatty acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid elongation, monounsaturated fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid elongation, polyunsaturated fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid elongation, saturated fatty acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid elongation, saturated fatty acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in very long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
very long chain fatty acid elongase 3
Names
3-keto acyl-CoA synthase Elovl3
ELOVL FA elongase 3
cold inducible glycoprotein 30
cold-inducible glycoprotein of 30 kDa
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
elongation of very long chain fatty acids protein 3
elongation of very long chain fatty acids-like 3
very long chain 3-ketoacyl-CoA synthase 3
very long chain 3-oxoacyl-CoA synthase 3
NP_001361594.1
NP_031729.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374665.1NP_001361594.1  very long chain fatty acid elongase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140233
    UniProtKB/TrEMBL
    A0A498WFQ4
    Related
    ENSMUSP00000036357.5, ENSMUST00000043739.6
    Conserved Domains (1) summary
    pfam01151
    Location:29244
    ELO; GNS1/SUR4 family
  2. NM_007703.2NP_031729.1  very long chain fatty acid elongase 3 isoform 1

    See identical proteins and their annotated locations for NP_031729.1

    Status: VALIDATED

    Source sequence(s)
    AA241332, U97107
    Consensus CDS
    CCDS29871.1
    UniProtKB/Swiss-Prot
    O35949
    Related
    ENSMUSP00000157465.2, ENSMUST00000237098.2
    Conserved Domains (1) summary
    pfam01151
    Location:52267
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46120336..46124133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)