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ELOVL3 ELOVL fatty acid elongase 3 [ Homo sapiens (human) ]

Gene ID: 83401, updated on 18-Aug-2020

Summary

Official Symbol
ELOVL3provided by HGNC
Official Full Name
ELOVL fatty acid elongase 3provided by HGNC
Primary source
HGNC:HGNC:18047
See related
Ensembl:ENSG00000119915 MIM:611815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIG30; CIG-30
Summary
This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]
Expression
Biased expression in fat (RPKM 1.4), skin (RPKM 0.7) and 8 other tissues See more
Orthologs

Genomic context

See ELOVL3 in Genome Data Viewer
Location:
10q24.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102224767..102229589)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103986143..103989346)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene PPARG related coactivator 1 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene paired like homeodomain 3 Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC107984263

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC21435

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-oxo-arachidoyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-cerotoyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-lignoceronyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
very-long-chain 3-ketoacyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
alpha-linolenic acid metabolic process TAS
Traceable Author Statement
more info
 
fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation, monounsaturated fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation, polyunsaturated fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation, saturated fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
linoleic acid metabolic process TAS
Traceable Author Statement
more info
 
long-chain fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
elongation of very long chain fatty acids protein 3
Names
3-keto acyl-CoA synthase ELOVL3
ELOVL FA elongase 3
cold-inducible glycoprotein of 30 kDa
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
very long chain 3-ketoacyl-CoA synthase 3
very long chain 3-oxoacyl-CoA synthase 3
NP_689523.1
XP_011538547.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152310.3NP_689523.1  elongation of very long chain fatty acids protein 3

    See identical proteins and their annotated locations for NP_689523.1

    Status: REVIEWED

    Source sequence(s)
    BC034344, HY050356
    Consensus CDS
    CCDS7531.1
    UniProtKB/Swiss-Prot
    Q9HB03
    Related
    ENSP00000359022.3, ENST00000370005.4
    Conserved Domains (1) summary
    pfam01151
    Location:29266
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    102224767..102229589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540245.2XP_011538547.1  elongation of very long chain fatty acids protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011538547.1

    UniProtKB/Swiss-Prot
    Q9HB03
    Conserved Domains (1) summary
    pfam01151
    Location:29266
    ELO; GNS1/SUR4 family
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