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Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A [ Mus musculus (house mouse) ]

Gene ID: 12683, updated on 8-Feb-2024

Summary

Official Symbol
Cideaprovided by MGI
Official Full Name
cell death-inducing DNA fragmentation factor, alpha subunit-like effector Aprovided by MGI
Primary source
MGI:MGI:1270845
See related
Ensembl:ENSMUSG00000024526 AllianceGenome:MGI:1270845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of sequestering of triglyceride. Acts upstream of or within lipid metabolic process and response to stilbenoid. Located in mitochondrial envelope and nucleus. Colocalizes with lipid droplet. Is expressed in brown fat. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 57.2), subcutaneous fat pad adult (RPKM 43.1) and 6 other tissues See more
Orthologs
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Genomic context

See Cidea in Genome Data Viewer
Location:
18 E1; 18 39.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67476634..67500864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67343564..67367794)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha stimulating, olfactory type Neighboring gene STARR-positive B cell enhancer ABC_E9173 Neighboring gene metallophosphoesterase 1 Neighboring gene STARR-seq mESC enhancer starr_44880 Neighboring gene STARR-positive B cell enhancer ABC_E7602 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67448542-67448843 Neighboring gene STARR-seq mESC enhancer starr_44887 Neighboring gene predicted gene, 30321 Neighboring gene RIKEN cDNA B430212C06 gene Neighboring gene inositol monophosphatase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10999 Neighboring gene tubulin, beta 6 class V Neighboring gene AFG3-like AAA ATPase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3234

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cold IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid droplet fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid droplet fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic DNA fragmentation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lipid transferase CIDEA
Names
cell death activator CIDE-A
cell death-inducing DFFA-like effector A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007702.2NP_031728.2  lipid transferase CIDEA

    See identical proteins and their annotated locations for NP_031728.2

    Status: VALIDATED

    Source sequence(s)
    BB614324, BQ554476, BQ554477
    Consensus CDS
    CCDS37846.1
    UniProtKB/Swiss-Prot
    O70302, Q4V9X2
    Related
    ENSMUSP00000025404.9, ENSMUST00000025404.10
    Conserved Domains (1) summary
    cd06539
    Location:33110
    CIDE_N_A; CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    67476634..67500864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)